APPROACHES TO COMPLEX CHIRAL QUATERNARY CARBON COMPOUNDS

复杂手性季碳化合物的研究方法

• 批准号: 2177355
• 负责人: ALBERT I MEYERS
• 金额: $ 20.5万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2177355
• 关键词: aspidosperma alkaloid; bicyclic compound; biological products; cyclopropanes; drug design /synthesis /production; drug screening /evaluation; gamma aminobutyrate; ketoacid; lactams; pheromone; pyrethroid; pyrrolidines; stereochemistry; stereoisomer; steroid analog; vinca alkaloids

A program to continue studies on the use of chiral bicyclic lactams as valuable precursors to a variety of enantiomerically pure substances is presented. This study, which began in 1985, has shown that a variety of reactions performed on these chiral templates lead to efficient syntheses of quaternary carbon compounds found in many important biologically active materials. The present proposal will extend these studies to heretofore unreported chiral pyrrolidines, octalones, [3,3,0] bicyclic enones, spirocyclopentenones as well as useful cyclopropane amino acids, isoquinolines, amines, and others - all in high enantiomeric purity. As a demonstration of this asymmetric methodology, synthetic routes to a number of pharmaceutically significant systems are outlined.

继续研究手性双环 作为多种对映体纯的有价值的前体的内酰胺 物质被提出。 这项始于1985年的研究表明， 在这些手性模板上进行的各种反应导致 季碳化合物的有效合成， 重要的生物活性物质。 目前的建议将这些研究扩展到迄今为止 未报道的手性吡咯烷，辛内酯，[3，3，0]双环烯酮， 螺环戊烯酮以及有用的环丙烷氨基酸， 异喹啉、胺和其它-都具有高对映体纯度。 作为 这种不对称方法的演示，合成路线， 概述了许多药学上重要的系统。