APPROACHES TO CHIRAL QUATERNARY CARBON COMPOUNDS

研究正在进行中，以继续评估不对称的 季碳化合物的合成 在最初两年的支持中有很大的潜力。 通过使用 由L-缬氨醇和α-缬氨醇容易制备的手性双环内酰胺 或γ-酮酸，（+）- mesembrine，（-）grandisol和（-）-cuparenone已被 完成了 我们现在希望进一步扩大范围， 这种强大的技术的生物碱的方法， aspidosperma和长春花类，triquinanes，脱落酸-有效 植物生长调节剂，三孢子酸-真菌调节剂， 卤喹啉-抗微生物剂，乙烯基环丙烷，拟除虫菊酯， 环丙胺类抗抑郁药，环丁烷类兴奋剂， 和大量有趣的手性非外消旋化合物， 药用价值 此外，机械和结构研究 将同时进行，以评估 这些双环内酰胺。

Studies are in progress to continue evaluation of an asymmetric synthesis of quaternary carbon compounds which have shown considerable potential in its first two years of support. By use of chiral bicyclic lactams, readily prepared from L-valinol and alpha or gamma-ketoacids, an asymmetric total synthesis of (+)- mesembrine, (-)grandisol, and (-)-cuparenone have been accomplished. We now wish to further extend the scope and methodology of this powerful technique to alkaloids of the aspidosperma and vinca class, triquinanes, abscisic acids-potent plant growth regulators, trisporic acids-fungal regulators, halenaquinol-anti-microbials, vinylcyclopropanes, pyrethroids, cyclopropylamines-anti-depressents, cyclobutanes-analegesics, and a host of interesting, chiral, non-racemic compounds of medicinal value. In addition, mechanistic and structural studies will be carried out concurrently to assess the full potential of these bicyclic lactams.