REDLAB Going Global - REDucing LABoratory Rodent Numbers by driving adoption of UK Technology

转基因动物的创造，主要是小鼠和大鼠，彻底改变了对动物模型中疾病过程的理解。转基因生物技术利用大量的动物：雌性和雄性产生用于基因操作的胚胎，雌性提供宿主子宫以支持胚胎的发育，不育的雄性诱导受孕雌性受孕。仅在英国，2014年就有120万只小鼠被用于培育转基因小鼠。科学家被要求遵守“三个R”(替换减少和精炼)的原则，以最大限度地减少实验中使用的动物数量，减少疼痛和痛苦。Ostara已经开发出一种专利的子宫系统，可以取代使用输精管切除的雄性来诱导假孕，并提高转基因胚胎在宿主母亲中的植入率。该项目将看到这项突破性技术得到展示和全球推广：获得广泛传播、收养和测试的目标可以减少80%的小鼠数量。

The creation of genetically modified animals, primarily mice and rats, has revolutionised understanding of disease processes in animal models. Transgenic biotechnologies utilise large numbers of animals: females and males to generate embryos for genetic manipulation, females to provide a host uterus to support the development of embryos, and infertile males to induce ‘pseudopregnancy’ in recipient females. In the UK alone, 1.2 million mice were used in breeding programmes for production of transgenic mice in 2014.Scientists are required to comply with the principle of the “Three Rs” (Replacement Reduction andRefinement) to minimize the number of animals used in experimentation and to reduce pain and suffering.Ostara has developed a patented pessary system that supersedes the use of vasectomised males in theinduction of pseudopregnancy and enhances transgenic embryo implantation rates in the host mothers.The project will see this breakthrough technology demonstrated and promoted globally: the objective of gaining widespread dissemination, adoption and tests can produce an 80% reduction mice numbers.