REDLAB Going Global - REDucing LABoratory Rodent Numbers by driving adoption of UK Technology

REDLAB 走向全球 - 通过推动英国技术的采用来减少实验室啮齿动物数量

• 批准号: 132625
• 金额: $ 2.45万
• 依托单位: OSTARA BIOMEDICAL LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=132625
• 关键词: REDLAB; Going; Global; REDucing; LABoratory

The creation of genetically modified animals, primarily mice and rats, has revolutionised understanding of disease processes in animal models. Transgenic biotechnologies utilise large numbers of animals: females and males to generate embryos for genetic manipulation, females to provide a host uterus to support the development of embryos, and infertile males to induce ‘pseudopregnancy’ in recipient females. In the UK alone, 1.2 million mice were used in breeding programmes for production of transgenic mice in 2014.Scientists are required to comply with the principle of the “Three Rs” (Replacement Reduction andRefinement) to minimize the number of animals used in experimentation and to reduce pain and suffering.Ostara has developed a patented pessary system that supersedes the use of vasectomised males in theinduction of pseudopregnancy and enhances transgenic embryo implantation rates in the host mothers.The project will see this breakthrough technology demonstrated and promoted globally: the objective of gaining widespread dissemination, adoption and tests can produce an 80% reduction mice numbers.

转基因动物的创造，主要是小鼠和大鼠，已经彻底改变了对动物模型疾病过程的理解。转基因生物技术利用大量的动物：雌性和雄性产生用于基因操作的胚胎，雌性提供宿主子宫以支持胚胎的发育，而不育的雄性在受体雌性中诱导“假怀孕”。仅在英国，2014年就有120万只老鼠被用于转基因老鼠的培育项目。科学家被要求遵守“3r”（替代、减少和细化）原则，以尽量减少用于实验的动物数量，并减少痛苦和折磨。Ostara已经开发了一种专利的子宫系统，取代了在诱导假妊娠中使用输精管切除的雄性，并提高了转基因胚胎在宿主母亲中的着床率。该项目将在全球范围内展示和推广这一突破性技术：获得广泛传播、采用和测试的目标可以使小鼠数量减少80%。