FOLLICLE STIMULATING HORMONE: CONTROL AND ACTION

卵泡刺激激素：控制和作用

• 批准号: 2198364
• 负责人: NEENA B SCHWARTZ
• 金额: $ 78.95万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2198364
• 关键词: follicle stimulating hormone; hormone regulation /control mechanism

The program represents the decision of multiple investigators to bring their individual techniques, systems and ideas to bear on a common theme. The central focus is the regulation of secretion and synthesis of the three pituitary gonadotropic hormones (FSH, LH and PRL), the analysis of their actions on the gonads and the feedback regulation by hormonal signals on the hypothalamic/pituitary unit. Particular emphasis is placed on the study of FSH because of the relative lack of information about his hormone compared to the other gonadotropins. The levels of investigation range from the whole animal to the molecular. The strong collaborations among the laboratories and projects have resulted in many important findings and an excellent publications record. The present application for renewal includes five research projects and an administrative core: PROJECT I. Differential Regulation of Gonadotropins by Glucocorticoids [Schwartz PI; Linzer CoPI] PROJECT II. Regulation of and Role of FSH in Photoperiodic Response [Turek PI; Levine Co-PI] PROJECT III. Protein Phosphorylation in Granulosa Cells [Hunzicker-Dunn PI] PROJECT IV. Inhibin and Activin: Synthesis, Activities, and Receptors [Mayo PI] PROJECT V. Regulation and Function of Ovarian Prolactin Receptors [Linzer PI; Hunzicker-Dunn Co-PI] CORE A. Administrative Core [Schwartz PD] The exchange of methodologies and ideas among investigators made possible by a Program Project Grant have fostered a broader perspective on the complexities of the hypothalamic-pituitary-gonadal axis than would have been possible with individual research grants. Indeed it is the interactions fostered by this Program Project Grant that have resulted in substantial progress being made in the past five years in understanding the control and action of FSH and the differences and similarities between FSH and the other gonadotropins.

该计划代表了多名调查人员的决定， 他们各自的技术、系统和想法都与一个共同的主题有关。 其中心焦点是调节细胞的分泌和合成， 三种垂体促性腺激素（FSH、LH和PRL）， 它们对性腺的作用和激素的反馈调节 下丘脑/垂体单位的信号。 特别强调 由于信息相对缺乏， 他的荷尔蒙和其他促性腺激素相比 水平 研究范围从整体动物到分子。 坚强 实验室和项目之间的合作产生了许多 重要的调查结果和出色的出版记录。 本 续期申请包括五个研究项目和一个 行政核心： 项目I. 糖皮质激素对促性腺激素的差异调节 [Schwartz PI; Linzer CoPI] 项目二. FSH在光周期反应中的调节和作用 [Turek PI; Levine Co-PI] 项目三. 颗粒细胞中的蛋白质磷酸化[Hunzicker-Dunn PI] 项目四. 抑制素和激活素：合成、活性和受体 [Mayo PI] 卵巢催乳素受体的调节和功能 [Linzer PI; Hunzicker-Dunn Co-PI] CORE A. 管理核心[Schwartz PD] 调查人员之间交流方法和想法， 通过计划项目赠款， 下丘脑-垂体-性腺轴的复杂性 个人研究赠款金。 的确， 本计划项目资助所促进的互动， 在过去五年中， 了解FSH的控制和作用，以及它们之间的差异， FSH和其他促性腺激素之间的相似性。