FOLLICLE STIMULATING HORMONE--CONTROL AND ACTION

卵泡刺激激素——控制和作用

• 批准号: 3097035
• 负责人: NEENA B SCHWARTZ
• 金额: $ 29.15万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3097035
• 关键词: follicle stimulating hormone; hormone regulation /control mechanism

While it has been recognized for many years that the anterior pituitary gland secretes two hormones which control the gonads-- follicle stimulating hormone and luteinizing hormone--we know far less about the control of secretion rate and mechanism of action for FSH than for LH. This application for a Program Project Grant outlines a multidisciplinary research effort aimed toward advancing our understanding of the control of the secretion rate of FSH by the anterior pituitary gland and of the mechanisms of action of the hormone on the ovary and testis. The application consists of the following projects and cores: Project I. Early Events in the Stimulation of Immature Porcine Granulosa Cells by FSH Project II. Regulation of FSH Secretion by the Perifused Pituitary Gland. Project III. Photoperiodic Control of FSH Secretion. Project IV. Neural Regulation of FSH Release: GnRH Release and Feedback Mechanisms Project V. Stress & Reproductive Function Project VI. Genes Encoding Gonadal FSH-Regulatory Hormones Core A. Radioimmunoassay Core B. Administration The present proposal represents the collaborative venture of 11 faculty members interested in reproductive endocrinology and representing 5 University departments to develop a unified program to improve our understanding of FSH. We expect that this combined thrust of in vivo and in vitro methodology, encompassing every level of the hypothalamic-pituitary-gonadal axis in experimental models and in humans, will add considerably to our basic knowledge about FSH and make it more feasible to consider FSH as a target in fertility and contraceptive research.

虽然多年来人们已经认识到前 垂体分泌两种控制性腺的激素—— 卵泡刺激素和黄体生成素——我们知道 更不用说分泌速率的控制和机制了 FSH 的作用高于 LH。 此程序申请 项目资助概述了一项多学科研究工作，旨在 加深我们对控制的理解 垂体前叶和促卵泡激素 (FSH) 的分泌率 激素对卵巢和睾丸的作用机制。 该应用程序由以下项目和核心组成： 项目一：刺激不成熟的早期事件 FSH 检测猪颗粒细胞 项目二。 灌注细胞对 FSH 分泌的调节 垂体。 项目三。 FSH 分泌的光周期控制。 项目四。 FSH 释放的神经调节：GnRH 发布及反馈机制 项目 V. 压力与生殖功能 项目六。 编码性腺 FSH 调节的基因 荷尔蒙 核心 A. 放射免疫分析 核心 B. 管理 本提案代表了 11 家机构的合作 对生殖内分泌学感兴趣的教职员工 代表5个大学院系制定统一的 计划来提高我们对 FSH 的了解。 我们期望 这种体内和体外方法的结合， 涵盖下丘脑-垂体-性腺的各个层面 实验模型和人体中的轴将大大增加 了解有关 FSH 的基础知识，并使其更加可行 将 FSH 视为生育和避孕研究的目标。