FOLLICLE STIMULATING HORMONE--CONTROL AND ACTION

卵泡刺激激素——控制和作用

• 批准号: 3097040
• 负责人: NEENA B SCHWARTZ
• 金额: $ 82.25万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1992-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3097040
• 关键词: follicle stimulating hormone; hormone regulation /control mechanism

While it has been recognized for many years that the anterior pituitary gland secretes two hormones which control the gonads-- follicle stimulating hormone and luteinizing hormone--we know far less about the control of secretion rate and mechanism of action for FSH than for LH. This application for a Program Project Grant outlines a multidisciplinary research effort aimed toward advancing our understanding of the control of the secretion rate of FSH by the anterior pituitary gland and of the mechanisms of action of the hormone on the ovary and testis. The application consists of the following projects and cores: Project I. Early Events in the Stimulation of Immature Porcine Granulosa Cells by FSH Project II. Regulation of FSH Secretion by the Perifused Pituitary Gland. Project III. Photoperiodic Control of FSH Secretion. Project IV. Neural Regulation of FSH Release: GnRH Release and Feedback Mechanisms Project V. Stress & Reproductive Function Project VI. Genes Encoding Gonadal FSH-Regulatory Hormones Core A. Radioimmunoassay Core B. Administration The present proposal represents the collaborative venture of 11 faculty members interested in reproductive endocrinology and representing 5 University departments to develop a unified program to improve our understanding of FSH. We expect that this combined thrust of in vivo and in vitro methodology, encompassing every level of the hypothalamic-pituitary-gonadal axis in experimental models and in humans, will add considerably to our basic knowledge about FSH and make it more feasible to consider FSH as a target in fertility and contraceptive research.

虽然多年来人们已经认识到， 脑下垂体分泌两种控制性腺的激素 促卵泡激素和促黄体激素--我们知道 更不了解分泌速率的控制和 FSH的作用大于LH。 此申请程序 项目赠款概述了多学科的研究工作，旨在 为了推进我们对控制 垂体前叶和垂体后叶的FSH分泌率 激素对卵巢和睾丸的作用机制。 该应用程序由以下项目和核心组成： 项目一 未成熟刺激中的早期事件 猪颗粒细胞（FSH法） 项目二. 外周血FSH分泌的调节 猪腺。 项目三. FSH分泌的光周期控制。 项目四. FSH释放的神经调节：GnRH 释放和反馈机制 项目五.压力与生殖功能 项目六. 编码性腺FSH调节的基因 激素 核心A。 放射免疫 核心B。 管理 本提案是11个国家的合作项目， 对生殖内分泌学感兴趣的教员， 代表5个大学部门制定统一的 这是为了提高我们对FSH的认识。 我们预计 这种体内和体外方法学的结合， 包括下丘脑-垂体-性腺 轴在实验模型和人类，将大大增加 我们对FSH的基本知识，使其更可行， 考虑FSH作为生育和避孕研究的目标。