ADAPTATIONS TO HYPOXIA

这是一次重新提交，寻求续签一项为期20年的计划 包括5个子项目，这些项目研究机制和 对低氧的不同反应的含义。其中三项仍在继续 关于肺病的长期调查 循环--血管收缩和肺的发展 对缺氧作出反应的高血压。拟议的研究探索了 低氧对肺血管内皮细胞和血管平滑肌的直接影响 肌肉、遗传决定因素和外膜的作用 成纤维细胞在缺氧性肺动脉高压形成中的作用 其他项目建议调查呼吸机对 低氧及其遗传因素的调节和低氧的影响 关于全身血管对怀孕的反应。有相当多的 这些项目之间在共同基础方面的相互影响 科学原则、共享的专业知识和资源。信息 这些研究的结果应该提供对影响的洞察力 缺氧对肺循环的影响，呼吸控制，以及 妊娠期间的全身循环变化。

This is a resubmission seeking renewal of a 20-year program encompassing 5 sub-projects which investigate mechanisms and implications of various responses to hypoxia. Three of these continue a long standing line of investigation concerning the pulmonary circulation-the development of vasoconstriction and pulmonary hypertension in response to hypoxia. The proposed studies explore direct effects of hypoxia on pulmonary vascular endothelium and smooth muscle, genetic determinants, and the role of the adventitial fibroblasts in the development of hypoxic pulmonary hypertension. Other projects propose to investigate the ventilatory response to hypoxia and its modulation by genetic factors and the effect of hypoxia on systemic vascular response to pregnancy. There is considerable cross-talk amongst these projects with respect to common underlying scientific principles, shared expertise and resources. Information resulting from these studies should provide insights into the effects of hypoxia on the pulmonary circulation, ventilatory control, and systemic circulatory changes in pregnancy.