ASYMMETRIC CATALYTIC HYDROSILATION AND HYDROACYLATION

不对称催化剂是酶的合成类似物，就像 少量的酶能够产生大量的 具有特定立体化学的产品。正因为如此，他们才是 生产对映体纯净材料的最有效方法 是生产生物活性分子所必需的。这 该项目旨在为生产提供高效的不对称催化 手性顺-1，3-二醇，3-取代环戊酮及其还原反应 前手性烯烃。所有的产品都很有用，有时还很关键 用于生产生物活性材料的起始材料。 该项目有两个目标，即实现高对映体过量 以及对催化机理的了解，以便开发一种 合理的设计基础。最终，我们预计当前的 涉及直觉和运气的方法将被更多的 严谨的科学方法。本提案试图 为这个长期目标做出贡献。

Asymmetric catalysts are synthetic analogues of enzymes and, like enzymes, small amounts are capable of generating large quantities of products with specific stereochemistry. Because of this, they are the most efficient way of generating enantiomerically pure materials which are required for the production of biologically active molecules. This project is directed at efficient asymmetric catalysis for the production of chiral cis-1,3-diols, 3-substituted cyclopentanones and the reduction of prochiral olefins. All of the products are useful and sometimes key starting materials for the production of biologically active materials. The project has the twofold goal of achieving high enantiomeric excesses and of understanding the mechanisms of catalysis in order to develop a rational basis for design. Ultimately, we expect that the current approaches which involve intuition and luck will be supplanted by a more rigorous scientific approach. The present proposal attempts to contribute to this long term goal.