ASYMMETRIC CATALYTIC HYDROSILATION AND HYDROACYLATION

不对称催化氢化硅烷化和氢化酰化

• 批准号: 3299828
• 负责人: BRICE BOSNICH
• 金额: $ 13.89万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3299828
• 关键词: acylation; alcohols; alkenes; catalyst; chemical synthesis; ketones; protonation; silicon compounds; stereoisomer

Asymmetric catalysts are synthetic analogues of enzymes and, like enzymes, small amounts are capable of generating large quantities of products with specific stereochemistry. Because of this, they are the most efficient way of generating enantiomerically pure materials which are required for the production of biologically active molecules. This project is directed at efficient asymmetric catalysis for the production of chiral cis-1,3-diols, 3-substituted cyclopentanones and the reduction of prochiral olefins. All of the products are useful and sometimes key starting materials for the production of biologically active materials. The project has the twofold goal of achieving high enantiomeric excesses and of understanding the mechanisms of catalysis in order to develop a rational basis for design. Ultimately, we expect that the current approaches which involve intuition and luck will be supplanted by a more rigorous scientific approach. The present proposal attempts to contribute to this long term goal.

不对称催化剂是酶的合成类似物， 少量的酶能够产生大量的 具有特定立体化学的产品。 正因为如此，他们是 产生对映体纯材料的最有效的方法 是生产生物活性分子所必需的。 这 该项目是针对高效的不对称催化生产 手性顺式-1，3-二醇，3-取代环戊酮和还原 前手性烯烃。 所有的产品都是有用的，有时是关键的， 用于生产生物活性材料的起始材料。 该项目有双重目标，实现高对映体过量 了解催化的机制，以便开发一种 设计的合理依据。 最终，我们预计， 涉及直觉和运气的方法将被更多的 严谨的科学方法。 本提案试图 为实现这一长期目标做出贡献。