RNA EDITING IN PLANT ORGANELLES
植物细胞器中的 RNA 编辑
基本信息
- 批准号:2188737
- 负责人:
- 金额:$ 21.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1994
- 资助国家:美国
- 起止时间:1994-05-01 至 1998-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
RNA editing can profoundly affect gene expression by altering the coding
capacity of a transcript. RNA editing has been reported in transcripts
from such organisms as trypanosomes, higher plants, and mammals. In
humans, RNA editing is necessary for proper expression of certain genes in
the brain and intestine. This process is responsible for the production
of two different apolipoproteins from the same gene; as the abundance of
one of these proteins is correlated with coronary artery disease, aberrant
RNA editing could potentially have serious health consequences. It is
likely that additional examples of RNA editing of human gene transcripts
remain to be discovered. We propose to study RNA editing in plant
organelles as a model for understanding this fundamental process that can
control gene expression. Like mammals, plant organelle editing results in
the modification of nucleotides rather than the insertion of nucleotides
that occurs in trypanosomes and other organisms. The editing activity in
chloroplasts and mitochondria may share features or even be identical. A
cryptic higher-level genetic code may be specifying which nucleotides are
to be altered by the editing process. Structural requirements for RNA
editing will be examined in vivo by introduction of chloroplast and
mitochondrial RNAs into transiently and stably transformed chloroplasts
obtained by particle bombardment. After information about RNA substrate
is available, studies will be carried out to characterize the components
of the editing activity. To learn whether there is a mechanism that
prevents synthesis of proteins from incompletely edited transcripts, or
whether translation of unedited RNAs results in multiple variant proteins,
we will isolate two mitochondrial proteins and characterize them
thoroughly. To determine whether editing has a role in gene regulation,
we will perform experiments to determine whether editing of particular
genes is tissue-specific.
RNA编辑可以通过改变编码深刻地影响基因表达
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MAUREEN REBECCA HANSON其他文献
MAUREEN REBECCA HANSON的其他文献
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{{ truncateString('MAUREEN REBECCA HANSON', 18)}}的其他基金
Probing the Pathophysiology of ME/CFS through Proteomics and Metabolomics
通过蛋白质组学和代谢组学探讨 ME/CFS 的病理生理学
- 批准号:
10237224 - 财政年份:2017
- 资助金额:
$ 21.86万 - 项目类别:
Cornell ME/CFS Collaborative Research Center Administrative Core
康奈尔大学 ME/CFS 合作研究中心行政核心
- 批准号:
10627288 - 财政年份:2017
- 资助金额:
$ 21.86万 - 项目类别:
Cornell ME/CFS Collaborative Research Center
康奈尔大学 ME/CFS 合作研究中心
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10237220 - 财政年份:2017
- 资助金额:
$ 21.86万 - 项目类别:
Microbiomes and Inflammation in Chronic Fatigue Syndrome
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Microbiomes and Inflammation in Chronic Fatigue Syndrome
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The Relationship of XMRV to Functional Status and Co-infections in Chronic Fatigu
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8084128 - 财政年份:2010
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$ 21.86万 - 项目类别:
The Relationship of XMRV to Functional Status and Co-infections in Chronic Fatigu
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7977530 - 财政年份:2010
- 资助金额:
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