Microbiomes and Inflammation in Chronic Fatigue Syndrome

慢性疲劳综合征中的微生物组和炎症

基本信息

  • 批准号:
    8496710
  • 负责人:
  • 金额:
    $ 18.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-07-01 至 2015-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Chronic fatigue syndrome (CFS) is a debilitating illness characterized by long-term fatigue and by other symptoms such as impaired memory or concentration, sore throat, tender lymph nodes, muscle pain, multi-joint pain, new headaches, unrefreshing sleep, and exercise intolerance. Individuals with CFS often exhibit gastrointestinal symptoms. While the cause(s) of chronic fatigue syndrome has not been established, a number of outbreaks implicate an infectious etiology. CFS patients exhibit both chronic activation and dysfunction of their immune systems. Increased levels of inflammatory cytokines could engender many of the symptoms of the illness. Cross-talk is known to occur between the intestinal immune cells and the microbes that reside in the gut. An altered community of gut microbes due to a dysfunctional immune system could be responsible for some CFS symptoms and contribute to chronic immune activation by affecting mucosal immunity and by disrupting intestinal integrity, thus allowing translocation of bacteria into blood from the gut. We will determine whether the types of bacteria found in the blood and gut differ between CFS patients and healthy individuals. The bacterial composition of the blood and gut microbiomes will be determined in 48 chronically ill individuals and compared to 24 healthy controls by pyrosequencing and analysis of 16S rDNA sequences. Assays will be performed to assess the expression levels of genes relevant to the immune system in human cells shed from the intestine. The amount of lactoferrin in stool samples will be determined as a measure of inflammation and bacterial endotoxin as an indication of intestinal dysfunction. Canonical correlation analysis will be used to identify correlated bacterial taxa and patterns of gene expression within patient subsets vs. healthy individuals. Such exploratory studies might suggest therapies to shift the gut microbiome toward that of healthier individuals in the hopes of ameliorating symptoms and could reveal whether trials of probiotics and antimicrobial or particular inflammation-modulating drugs may be warranted. Because characterization of the human microbiota is just beginning, our analyses will also make a valuable contribution to knowledge about the diversity of microbes associated with CFS.
描述(由申请人提供):慢性疲劳综合征(CFS)是一种使人衰弱的疾病,其特征是长期疲劳和其他症状,如记忆力或注意力受损、咽喉痛、淋巴结触痛、肌肉疼痛、多关节疼痛、新发头痛、睡眠不振和运动不耐受。CFS患者经常表现出胃肠道症状。虽然慢性疲劳综合征的病因尚未确定,但一些暴发涉及感染性病因。CFS患者表现出免疫系统的慢性激活和功能障碍。炎性细胞因子水平的增加可能引起疾病的许多症状。众所周知,肠道免疫细胞和肠道中的微生物之间会发生串扰。由于免疫系统功能失调而改变的肠道微生物群落可能是导致某些CFS症状的原因,并通过影响粘膜免疫和破坏肠道完整性而导致慢性免疫激活,从而使细菌从肠道易位到血液中。我们将确定CFS患者和健康个体之间血液和肠道中发现的细菌类型是否不同。将在48名慢性病患者中确定血液和肠道微生物组的细菌组成,并通过焦磷酸测序和16S rDNA序列分析与24名健康对照进行比较。将进行测定以评估从肠脱落的人细胞中与免疫系统相关的基因的表达水平。粪便样品中乳铁蛋白的量将被确定为炎症和细菌内毒素的量度,作为肠功能障碍的指示。典型相关分析将用于鉴定患者亚组与健康个体内相关的细菌分类群和基因表达模式。这些探索性研究可能会建议将肠道微生物组转移到健康个体的治疗方法,以期改善症状,并可能揭示益生菌和抗微生物或特定炎症调节药物的试验是否有必要。由于对人类微生物群的表征才刚刚开始,我们的分析也将为了解与CFS相关的微生物多样性做出宝贵贡献。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome.
  • DOI:
    10.1186/s40168-016-0171-4
  • 发表时间:
    2016-06-23
  • 期刊:
  • 影响因子:
    15.5
  • 作者:
    Giloteaux L;Goodrich JK;Walters WA;Levine SM;Ley RE;Hanson MR
  • 通讯作者:
    Hanson MR
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MAUREEN REBECCA HANSON其他文献

MAUREEN REBECCA HANSON的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MAUREEN REBECCA HANSON', 18)}}的其他基金

Probing the Pathophysiology of ME/CFS through Proteomics and Metabolomics
通过蛋白质组学和代谢组学探讨 ME/CFS 的病理生理学
  • 批准号:
    10237224
  • 财政年份:
    2017
  • 资助金额:
    $ 18.21万
  • 项目类别:
Cornell ME/CFS Collaborative Research Center Administrative Core
康奈尔大学 ME/CFS 合作研究中心行政核心
  • 批准号:
    10627288
  • 财政年份:
    2017
  • 资助金额:
    $ 18.21万
  • 项目类别:
Cornell ME/CFS Collaborative Research Center
康奈尔大学 ME/CFS 合作研究中心
  • 批准号:
    10237220
  • 财政年份:
    2017
  • 资助金额:
    $ 18.21万
  • 项目类别:
Circulating signals of ME/CFS
ME/CFS 循环信号
  • 批准号:
    10627291
  • 财政年份:
    2017
  • 资助金额:
    $ 18.21万
  • 项目类别:
Microbiomes and Inflammation in Chronic Fatigue Syndrome
慢性疲劳综合征中的微生物组和炎症
  • 批准号:
    8359145
  • 财政年份:
    2012
  • 资助金额:
    $ 18.21万
  • 项目类别:
The Relationship of XMRV to Functional Status and Co-infections in Chronic Fatigu
XMRV 与慢性疲劳功能状态和合并感染的关系
  • 批准号:
    8084128
  • 财政年份:
    2010
  • 资助金额:
    $ 18.21万
  • 项目类别:
The Relationship of XMRV to Functional Status and Co-infections in Chronic Fatigu
XMRV 与慢性疲劳功能状态和合并感染的关系
  • 批准号:
    7977530
  • 财政年份:
    2010
  • 资助金额:
    $ 18.21万
  • 项目类别:
RNA EDITING IN PLANT ORGANELLES
植物细胞器中的 RNA 编辑
  • 批准号:
    6385864
  • 财政年份:
    1994
  • 资助金额:
    $ 18.21万
  • 项目类别:
RNA EDITING IN PLANT ORGANELLES
植物细胞器中的 RNA 编辑
  • 批准号:
    2188737
  • 财政年份:
    1994
  • 资助金额:
    $ 18.21万
  • 项目类别:
RNA EDITING IN PLANT ORGANELLES
植物细胞器中的 RNA 编辑
  • 批准号:
    2188736
  • 财政年份:
    1994
  • 资助金额:
    $ 18.21万
  • 项目类别:

相似海外基金

Web-based Pain Coping Skills Training to Improve Pain and Poor Adherence caused by Aromatase Inhibitor-Associated Arthralgia In Breast Cancer Survivors (SKIP-Arthralgia): A Randomized Controlled Trial
基于网络的疼痛应对技能培训,以改善乳腺癌幸存者芳香酶抑制剂相关关节痛引起的疼痛和依从性差(SKIP-关节痛):一项随机对照试验
  • 批准号:
    10439192
  • 财政年份:
    2022
  • 资助金额:
    $ 18.21万
  • 项目类别:
Web-based Pain Coping Skills Training to Improve Pain and Poor Adherence caused by Aromatase Inhibitor-Associated Arthralgia In Breast Cancer Survivors (SKIP-Arthralgia): A Randomized Controlled Trial
基于网络的疼痛应对技能培训,以改善乳腺癌幸存者芳香酶抑制剂相关关节痛引起的疼痛和依从性差(SKIP-关节痛):一项随机对照试验
  • 批准号:
    10630101
  • 财政年份:
    2022
  • 资助金额:
    $ 18.21万
  • 项目类别:
Clarification of the mechanism for arthralgia, one of the premenstrual syndrome symptoms, focusing on the extracellular matrix
阐明经前综合症症状之一的关节痛的机制,重点关注细胞外基质
  • 批准号:
    17K11262
  • 财政年份:
    2017
  • 资助金额:
    $ 18.21万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Estrogen Deprivation and Aromatase Inhibitor associated Arthralgia
雌激素剥夺和芳香酶抑制剂相关的关节痛
  • 批准号:
    8086843
  • 财政年份:
    2011
  • 资助金额:
    $ 18.21万
  • 项目类别:
Estrogen Deprivation and Aromatase Inhibitor associated Arthralgia
雌激素剥夺和芳香酶抑制剂相关的关节痛
  • 批准号:
    8291088
  • 财政年份:
    2011
  • 资助金额:
    $ 18.21万
  • 项目类别:
Estrogen Deprivation and Aromatase Inhibitor associated Arthralgia
雌激素剥夺和芳香酶抑制剂相关的关节痛
  • 批准号:
    8660047
  • 财政年份:
    2011
  • 资助金额:
    $ 18.21万
  • 项目类别:
Estrogen Deprivation and Aromatase Inhibitor associated Arthralgia
雌激素剥夺和芳香酶抑制剂相关的关节痛
  • 批准号:
    8847227
  • 财政年份:
    2011
  • 资助金额:
    $ 18.21万
  • 项目类别:
Development of the way of Nordic Walking for elderly people with arthralgia and verification of its intervention effect.
老年人关节痛北欧式健走方式的开发及干预效果验证
  • 批准号:
    23700636
  • 财政年份:
    2011
  • 资助金额:
    $ 18.21万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Estrogen Deprivation and Aromatase Inhibitor associated Arthralgia
雌激素剥夺和芳香酶抑制剂相关的关节痛
  • 批准号:
    8461818
  • 财政年份:
    2011
  • 资助金额:
    $ 18.21万
  • 项目类别:
Estrogen Deprivation and Aromatase Inhibitor associated Arthralgia
雌激素剥夺和芳香酶抑制剂相关的关节痛
  • 批准号:
    9276333
  • 财政年份:
    2011
  • 资助金额:
    $ 18.21万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了