C-H to C-F using electrochemistry and gold catalysis

使用电化学和金催化将 C-H 转化为 C-F

• 批准号: DP200100013
• 负责人: Prof Jason Dutton
• 金额: $ 26万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100013
• 关键词: using; electrochemistry; gold; catalysis

Gold offers great potential in chemical catalysis and this project will use a fascinating new class of gold compounds discovered by the CIs, to develop novel catalysts. Using this chemistry a series of gold(III) compounds with fluoride ligands will be prepared. The catalytic properties of these molecules will then be explored, with a particular focus on adding value to arene hydrocarbons. The ultimate goal of the project is development of new catalysts for the formation of carbon-fluorine bonds and the selective fluorination of organic compounds. Fluorinated organic molecules are of critical importance in medicinal chemistry and new catalysts of this type offers the potential for better synthesis of medicines and diagnostic agents.

金在化学催化方面具有巨大的潜力，该项目将使用CI发现的一种迷人的新型金化合物来开发新型催化剂。使用这种化学方法，将制备一系列具有氟化物配体的金（III）化合物。然后将探索这些分子的催化性能，特别关注芳烃的增值。该项目的最终目标是开发新的催化剂，用于形成碳-氟键和选择性地取代有机物。 化合物.含氟有机分子在药物化学中至关重要，这种类型的新催化剂为更好地合成药物和诊断剂提供了潜力。