The Nanopore-based Ion Selective Electrode Vial

基于纳米孔的离子选择电极瓶

• 批准号: 10325420
• 负责人: Sean German
• 金额: $ 35万
• 依托单位: ELECTRONIC BIOSCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2023-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10325420
• 关键词: Anion Gap; Biological; Biological Assay; Biological Markers; Biological Sciences; Blood; Blood Tests; Blood specimen; Brain; Buffers; Calcium; Calibration; Carbon Dioxide; Charge; Chelating Agents; Chemicals; Chemistry; Chronic Kidney Failure; Collection; Complete Blood Count; Dependence; Detection; Development; Devices; Diagnosis; Electrochemistry; Electrodes; Electrolytes; Electronics; Elements; Emergency Medicine; Ensure; Enzyme Electrodes; Enzymes; Equation; Equilibrium; Evaluation; Filtration; Fingers; Fluid Balance; Food Energy; Foundations; German population; Glass; Gold; Health; Home; Individual; Ion Exchange; Ion-Selective Electrodes; Ions; Iron; Laboratories; Maintenance; Manuals; Measurable; Measurement; Measures; Medical; Membrane; Metabolic; Methodology; Molecular; Monitor; Muscle Contraction; Nanotechnology; Nutrient; Patient Care; Patient-Focused Outcomes; Patients; Performance; Pharmaceutical Preparations; Phase; Physicians; Physiological; Plasma; Polymers; Potassium; Potassium Chloride; Process; Reader; Sampling; Side; Signal Transduction; Small Business Technology Transfer Research; Sodium; Specialist; Structure; System; Systems Development; Systems Integration; Techniques; Technology; Technology Assessment; Temperature; Testing; Thyroid Gland; Time; Traction; Tube; Universities; Utah; Vial device; Vitamin B Complex; Waste Products; Whole Blood; Work; base; care outcomes; cost; crystallinity; design; electric impedance; electrical measurement; electrical potential; experience; heart rhythm; home test; improved; miniaturize; nanopore; negative affect; point of care; point of care testing; professor; programs; prototype; response; sensor; theories

Project Summary An electrolyte panel is a blood test that measures the levels of electrolytes and carbon dioxide in your blood. Electrolytes are chemicals found naturally in the body, such as potassium, calcium, sodium, and are needed to keep the body's balance of fluids at the proper level and to maintain normal functions, such as heart rhythm, muscle contraction, and brain function. CO2 is a waste product made when the body breaks down food for energy, CO2 helps your blood stay at the right pH. Physicians may order an electrolyte panel as part of a regular health examination, to check on or diagnose a medical condition, and/or assess whether medications are negatively affecting one electrolyte levels. Electrolyte panels are currently typically carried out as laboratory test, where a blood sample is sent out to be characterized via manual ion selective electrodes (ISEs). This process takes a significant amount of time, is cost inefficient, and has issues associated with the fragility and maintenance of manual ISEs. And, while there has been the development of point-of-care or handheld electrolyte panel systems, these current systems have failed to gain widespread use or traction, due to issues with stability, storability, accuracy, and inability to be combined with other assays for comprehensive blood work analyses, i.e. complete blood count (CBC), chemistry (basic metabolic) panel, thyroid panel, nutrient tests for levels of vital nutrients, such as iron or B vitamins, enzyme markers, and STDs. Recently however, Professor Henry S. White at the University of Utah has developed a new nanopore-based ISE technology that solves the predominant issues of conventional ISEs, can be multiplexed to a high degree, can be mass fabricated and can be easily combined with other nanopore-based characterization techniques for complete blood work analyses on a single device. During this Phase 1 STTR program, Electronic BioSciences will develop and expand upon Professor White’s nanopore-based ISE technology, developing a storable, highly stable, rapid, and accurate electrolyte panel POC testing vial. The utility of this device will be demonstrated characterizing electrolyte abnormalities in blood samples from chronic kidney disease patients.

项目摘要 电解质面板是一种血液测试，可测量血液中电解质和二氧化碳的水平。 电解质是体内自然发现的化学物质，例如钾，钙，钠，需要 保持身体的液体平衡状态，并保持正常功能，例如心律， 肌肉收缩和大脑功能。二氧化碳是当身体分解食物的废物 能量，二氧化碳可以帮助您的血液保持正确的pH值。医师可以订购电解质面板作为常规的一部分 健康检查，检查或诊断医疗状况和/或评估药物是否为 负面影响一个电解质水平。目前，电解质面板通常作为实验室测试进行， 通过手动离子选择性电极（ISE）寄出血液样本以表征为表征。这个过程 花费大量时间，成本无效，并且存在与脆弱性和维护相关的问题 手动ises。而且，尽管已经开发了护理点或手持电解质面板 由于稳定性问题，系统，这些当前系统未能获得广泛使用或牵引力， 可持续性，准确性和无法与其他测定法相结合，以进行全面的血液工作分析，即 全血数（CBC），化学（基本代谢）面板，甲状腺面板，营养测试的重要水平 营养素，例如铁或B族维生素，酶标记物和STD。但是最近，亨利·怀特教授 犹他大学在犹他大学开发了一种新的基于纳米孔的ISE技术，该技术解决了主要的ISE技术 常规ISE的问题，可以高度多样化，可以批量制造，并且可以轻松地进行 结合其他基于纳米孔的表征技术，用于单个单一的血液工作分析 设备。在此阶段1 STTR计划中，电子生物科学将在教授上发展和扩展 怀特的基于纳米孔的ISE技术，开发了一种可存储，高度稳定，快速和准确的电解质 面板POC测试小瓶。该设备的效用将被证明表征了电解质异常 慢性肾脏病患者的血液样本。