PREGNANCY AND EXERCISE

怀孕和运动

• 批准号: 2198196
• 负责人: JAMES F CLAPP
• 金额: $ 13万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2198196
• 关键词: blood chemistry; calorimetry; cell morphology; electrical conductance; embryo /fetus; embryology; exercise; female; human pregnant subject; morphology; perinatal; placenta; pregnancy; pregnancy circulation; ultrasonography

This proposal is designed to prospectively examine the interaction between two types of endurance exercise and the course and outcome of pregnancy. Its goal is to test the broad hypothesis that, above a threshold level, endurance types of exercise have a negative, dose-response effect on multiple aspects of the reproductive process in female recreational endurance athletes. Data addressing potential mechanisms for this effect will be obtained by evaluating each subject's physiological response to exercise. Over 5 years the actual exercise performance and the cardiovascular, metabolic, respiratory, and thermal response to two types of endurance exercise will be evaluated in 150 well-conditioned women prior to and during pregnancy. 75 runners and 75 aerobic dancers form the study populace which will be prospectively matched with a control group. Subsets of these groups will be used to evaluate specific physiological responses in greater detail. Methodologies include: underwater weighing and skinfold measurements for assessing body composition; a daily exercise log and portable heart rate monitor for assessing actual exercise performance; treadmill testing with appropriate respiratory and thermal equipment for assessing VO2 max and the metabolic, respiratory and thermal response to exercise; menstrual record, Beta-subunit and ultrasound for accurate pregnancy dating, standard enzymati and RIA methodologies for measurement of blood levels of catecholamines, glucose, lactate, insulin and cortisol; and standard morphometric techniques for assessment of fetal, placental and neonatal growth. The physiological data and exercise log will be used to calculate both time-specific and cumulative exercise stress expressed as a duration-intensity index. This independent variable will be correlated with multiple reproductive outcome variables such as: fertility; early and late pregnancy complications; course of labor and delivery; neonatal and placental morphometrics; and, growth through the first year of life. Specific subsets of physiological data will be used to assess the potential mechanisms likely to be involved in the interaction. Currently, there is a paucity of information in this area and the information obtained will have direct application to 25% of women considering pregnancy.

本提案旨在前瞻性地研究 两种类型的耐力运动和怀孕的过程和结果。 其目的是检验一个广泛的假设，即在阈值水平以上， 耐力类型的运动有负面的，剂量反应效应， 女性娱乐生殖过程的多个方面 耐力运动员 说明该效应潜在机制的数据 将通过评估每个受试者的生理反应来获得， 锻炼的 超过5年的实际运动表现和心血管， 代谢，呼吸和热反应的两种类型的耐力 将在150名身体状况良好的妇女中进行评估， 孕期 75名跑步者和75名有氧舞蹈者组成了这项研究 将与对照组前瞻性匹配的人群。 子集 将用于评估特定的生理反应 更详细地说。 方法包括：水下称重和 用于评估身体成分的皮褶测量;每日运动日志 和便携式心率监测器，用于评估实际运动表现; 使用适当的呼吸和热设备进行跑步机测试， 评估最大摄氧量和代谢、呼吸和热反应， 运动;月经记录，β-亚单位和超声准确 妊娠期测定、标准酶法和RIA法 血液中的儿茶酚胺、葡萄糖、乳酸、胰岛素和皮质醇水平; 以及用于评估胎儿、胎盘和 新生儿生长 生理数据和运动日志将用于计算两者 时间特异性和累积运动应力表示为 持续强度指数 这个自变量将与 多个生殖结果变量，如：生育率;早期和 晚期妊娠并发症;产程和分娩;新生儿和 胎盘形态测量学;以及，生命第一年的生长。 生理数据的特定子集将用于评估潜在的 可能参与相互作用的机制。 目前，有一个 缺乏这方面的资料，所获得的资料将 直接应用于25%考虑怀孕的妇女。