THE SIGNIFICANCE OF AN ANTENATAL NUCHAL CORD

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是确定无症状的产前脐带的存在是否具有临床意义，如果是，辅助发现是否对制定管理计划有任何潜在的价值。在某些情况下，分娩过程中的脐带绕颈与胎儿窘迫和不良结局有关。妊娠和分娩期间脐带绕颈的真实发生率，以及在这些时间段发生脐带绕颈的婴儿的结局尚不清楚。每名孕妇将在24-26周、30-32周、36-38周和分娩时进行研究。具体的产前测量包括脐带绕颈的超声检测、非应激试验、生物物理特征以及脐血和脑循环的矢量测量。后续研究将在婴儿出生五天和一岁时进行，包括形态测量和神经发育参数。脐带绕颈的存在将与当时的生物物理测试和婴儿的结局(生长、头部超声和贝利评分)相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if the presence of an asymptomatic antenatal nuchal cord has clinical significance and, if so, are ancillary findings of any potential value in formulating a management plan. Nuchal cords during labor are associated with fetal distress and poor outcomes in some cases. The true incidence of nuchal cords during pregnancy and labor, and the outcome of infants with nuchal cords at these times is unknown. Each pregnant woman will be studied at 24-26 weeks, 30-32 weeks, 36-38 weeks, and labor. Specific antenatal measurements include ultrasonic detection of a nuchal cord, non-stress test, biophysical profile and vecilometry of the umbilical and brain circulation. Follow-up studies will be done in the infants at five days and one year of life and include morphometric and neurodevelopmental parameters. The presence of nuchal cord will be correlated with biophysical testing at that time and outcomes in the infant (growth, head ultrasound, and Bayley scores).