Connected and intelligent device for personalised diagnostic, treatment and management of sleep breathing disorders. SnooZeal-Connect

用于睡眠呼吸障碍的个性化诊断、治疗和管理的互联智能设备。

• 批准号: 26526
• 金额: $ 102.23万
• 依托单位: SIGNIFIER MEDICAL TECHNOLOGIES LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=26526
• 关键词: Connected; intelligent; device; personalised; diagnostic

Obstructive Sleep Apnoea is a condition where the muscles and soft tissues in the throat relax and collapse sufficiently to cause a total blockage of the airway for 10 seconds or more during sleep. OSA is a potentially deadly condition in extreme cases but for moderate OSA patients, fatigue from regularly disturbed sleep can impact heavily on quality of life. If left untreated, the condition increases the risks of high blood pressure, coronary heart disease, stroke and diabetes. Current treatment requires the continual use of airway obstruction preventative devices worn whilst sleeping. They do not offer any improvement in the underlying cause and are therefore required for nocturnal use for the rest of the person's life. OSA affects approximately 1.5mn people within the UK and despite the market size for sleep apnoea devices being $4.4Bn in 2017, there remains no product that can treat the condition with only surgery as a last resort in severe cases with no guarantee of success.Snoozeal have developed a device which fits onto the tongue to deliver a daily 20min treatment regime which changes the physiology of the contracting muscle at the rear of the tongue through mild electric pulses, or neuromodulation. Increasing the tongue tone stops it collapsing backwards and blocking the airway, providing a long-term cure.This project will further develop the Snoozeal device into a connected intelligent platform "SnooZeal-Connect" which will collect biosensor information from the device during treatment. Machine-learning and AI based methods will classify this data to determine the level of sleep apnoea and provide personalised treatment regimes. SnooZeal-Connect will facilitate low-cost convenient intervention at home and close the health and well-being gap for millions of sufferers. It will also reduce the burden on health services by reducing the direct cost of treating severe sleep apnoea, as well as the cost of treating the long-term health impacts from OSA.

阻塞性睡眠呼吸暂停是一种情况下，肌肉和软组织在喉咙放松和塌陷足以导致气道完全堵塞10秒或更长的睡眠期间。在极端情况下，OSA是一种潜在的致命疾病，但对于中度OSA患者来说，由于睡眠经常受到干扰而产生的疲劳会严重影响生活质量。如果不及时治疗，这种情况会增加患高血压、冠心病、中风和糖尿病的风险。目前的治疗需要持续使用睡眠时佩戴的气道阻塞预防装置。它们不能改善根本原因，因此需要在人的余生中夜间使用。OSA影响英国约150万人，尽管2017年睡眠呼吸暂停设备的市场规模为44亿美元，目前还没有一种产品可以治疗这种疾病，在严重的情况下，只有手术作为最后的手段，不能保证成功。Snoozeal开发了一种装置，可以安装在舌头上，每天提供20分钟的治疗方案，改变收缩肌肉的生理机能通过温和的电脉冲或神经调节在舌头后部。增加舌头的音调可以防止舌头向后塌陷并阻塞气道，从而提供长期治疗。该项目将进一步将Snoozeal设备开发成一个连接的智能平台“SnooZeal-Connect”，该平台将在治疗期间从设备收集生物传感器信息。基于机器学习和人工智能的方法将对这些数据进行分类，以确定睡眠呼吸暂停的水平，并提供个性化的治疗方案。SnooZeal-Connect将促进低成本的家庭便利干预，并缩小数百万患者的健康和福祉差距。它还将通过降低治疗严重睡眠呼吸暂停的直接成本以及治疗OSA长期健康影响的成本来减轻卫生服务的负担。