EPIDEMIOLOGY OF CARDIOVASCULAR RISK FACTORS IN WOMEN

女性心血管危险因素的流行病学

• 批准号: 2216253
• 负责人: LEWIS H KULLER
• 金额: $ 38.65万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2216253
• 关键词: EPIDEMIOLOGY; CARDIOVASCULAR; RISK; FACTORS; WOMEN

The Healthy Women Study of cardiovascular disease among women recruited 541 premenopausal women between the ages of 42-50 from 1983-84. The goal of the study has been to describe the changes in risk factors for cardiovascular disease during the pre-, peri- and postmenopause, the relationship of risk factor changes to life-style, behavioral and psychological attributes, sex-steroid hormones and insulin, and the use and effect of hormone replacement therapy on risk factors. Most of the women are now postmenopausal, and in their middle 50's. Approximately 40% are using hormone replacement therapy. The response rate at 5th postmenopausal exam is approximately 80%. We have documented the substantial increase in LDLc, blood insulin, decreased HDL2c, and clotting factor changes during the peri- to postmenopause. There is an approximate one pound per year gain in weight, i.e. 10-12 pounds over 10 years, and increased waist-to-hip ratio related to weight gain. The blood estrone levels increase with weight postmenopausally. Decreased exercise was linked to weight gain. Women who became menopausal were not more depressed, anxious or distressed than their age-matched premenopausal controls or postmenopausal women taking hormones. The only subgroup vulnerable to depression during the menopausal transition were women who elected to use hormones and had low self esteem at baseline evaluation. We have documented a high prevalence of carotid artery plaque (57%) and a strong relationship between plaque and baseline (premenopause) LDLc, HDLc, insulin and other risk factors, and blood pressure to wall thickness. We propose to continue follow-up to determine characteristics of changes in risk factors, behavioral/psychological attributes and to determine the relationship between risk factors, and their changes and atherosclerosis, plaque and wall thickness. We will determine the interrelationship of lifestyle and behavioral attributed to sex-steroid hormones and insulin and the level of hormones to atherosclerosis. We will determine the association of lifestyle to amount and distribution of body fat measured by DEXA and CT of the abdomen.

健康女性心血管疾病研究 1983 - 84年，541名年龄在42 - 50岁之间的绝经前妇女。目标 这项研究的目的是描述 绝经前、绝经中和绝经后的心血管疾病， 危险因素变化与生活方式、行为和 心理属性，性类固醇激素和胰岛素，以及使用 以及激素替代治疗对危险因素的影响。 大多数妇女现在已经绝经，50多岁了。 大约40%的人正在使用激素替代疗法。响应 第5次绝经后检查的比率约为80%。 我们已经记录了LDLc，血胰岛素， HDL2c降低和凝血因子变化， 绝经后体重每年大约增加一磅， 即10 - 12磅超过10年，并增加腰臀比有关 体重增加。血液雌酮水平随体重增加而增加 绝经后运动量减少与体重增加有关。 绝经后的女性并没有比绝经前的女性更抑郁、焦虑或抑郁。 比年龄匹配的绝经前对照组更痛苦， 服用激素的绝经后妇女唯一容易受到 绝经过渡期抑郁症的妇女选择使用 激素和低自尊在基线评估。 我们记录了颈动脉斑块的高患病率（57%）， 斑块与基线（绝经前）LDL c之间存在强相关性， HDLc、胰岛素和其他危险因素与血压相关 厚 我们建议继续跟踪，以确定变化的特征 风险因素，行为/心理属性，并确定 危险因素及其变化与动脉粥样硬化的关系， 斑块和壁厚。我们将确定 生活方式和行为归因于性类固醇激素和胰岛素 以及激素水平与动脉粥样硬化的关系。康贝特人将以 生活方式与测量的体脂量和分布的关系 通过DEXA和腹部CT。