FIBER OPTIC SENSOR FOR MEASURING LEAD IN BLOOD

在第一阶段，Innovation Associates展示了 一种测量感兴趣水平铅的光纤传感器的研制 去血液筛查诊所。铅离子选择光纤电极(LISFO) 在2-200之间的响应曲线的线性部分运行 微克/分升(新的疾控中心关注水平)。光纤技术的使用 将提供坚固、紧凑的便携式仪器，并允许低成本 对血铅浓度进行筛查。在第二阶段， 将优化条件以确保光纤间的重现性， 样品制备方法将得到优化和自动化，并将在 原型将通过平行测量构建和验证 LISFO和AAS的临床样本比较。该仪器将与 具有一台PC，它将调节自动操作、处理和报告 这样，经过最低限度培训的操作员就可以获得可靠的结果 几乎没有受到样本污染的机会。用户界面将 允许输入患者信息。 以前在诊所使用的铅筛查不再准确 在关注的层面上阅读。因此，需要一种新的 可供受过有限培训的人员使用的仪器 可提供大规模、低成本的血铅水平检测。这个 建议的仪器将满足铅筛查诊所的要求 并将在那个市场上被接受。

During Phase I, Innovation associates demonstrated the feasibility of developing a fiber optic sensor for measuring lead at levels of interest to blood screening clinics. The Lead Ion Selective Fiber Optrode (LISFO) operates in the linear portion of the response curve between 2-200 microg/dL (the new CDC level of concern). Use of fiber optic technology will provide a rugged, compact portable instrument and allow low cost screenings of blood lead concentrations to be performed. During Phase II, conditions will be optimized to insure inter-fiber reproducibility, sample preparation methods will be optimized and automated, and a pre- prototype will be constructed and validated by parallel measurements on clinical samples comparing LISFO with AAS. The instrument will interface with a PC which will regulate automatic operations and process and report data so that minimally trained operators can achieve reliable results with little opportunity for sample contamination. A user interface will permit entry of patient information. PROPOSED COMMERCIAL APPLICATION: Since the CDC lowered the level of concern for lead in blood to 10 microg/dL, the instruments which have previously been used in lead screening clinics no longer give accurate reading at the level of concern. Consequently, there is a need for a new instrument which is usable by personnel with limited training and which can provide large scale, low cost testing of blood lead levels. The proposed instrument will meet the requirements of lead screening clinics and will find acceptance in that market.