CORTICOCORTICAL INTERACTIONS IN VISION

灵长类视觉系统中的皮质-皮质相互作用 调查了解之间的通信的性质 皮质区和皮质区如何在分析中相互作用， 视觉世界 将在纹状体和纹状体之间进行成对电生理记录。 清醒猴纹外区V1/V4、V1/IT和V4/IT。 将在麻醉猴中进行类似的实验。视觉 刺激将包括宽带和带限噪声， 允许皮层特征提取分离刺激 从简单的空间过滤机制。穗火车和当地 将分析两个视觉区域中记录的场电位， 有无视觉刺激时的互相关结构 以及视觉引导行为的存在和不存在。 皮质-皮质相互作用将在三种不同的行为模式中进行研究。 contexts. 1)选择性特征注意; 同时对比的感觉。当前的皮质 组织建议，这些行为应该影响 不同皮层区域之间的相互作用 V_1和V_2皮层活动的时间和分布 V4将在麻醉后用多触点电极检查 猴子.这项研究将解决下降预测的作用， 纹外皮层V1区对视觉形式的加工。 神经纤维缠结的区域性和层状模式导致了 结论：与阿尔茨海默病相关的痴呆是一种 皮质皮质投射丧失的结果。的发展 更准确的诊断技术可能取决于更好的 了解灵长类动物皮质相互作用的本质 个脑袋

Corticocortical interactions in the primate visual system will be investigated to learn about the nature of the communication between cortical areas and how cortical regions interact in the analysis of the visual world. Paired electrophysiological recordings will be made between striate and extrastriate areas V1/V4, V1/IT and V4/IT in the awake-behaving monkey. Similar experiments will be performed in anesthetized monkeys. Visual stimuli will consist of both broadband and bandlimited noise as well as stimuli that allow for a separation of cortical feature extraction mechanisms from those of simple spatial filtering. Spike trains and local field potentials recorded in two visual areas will be analyzed for crosscorrelation structure in the presence and absence of visual stimuli and in the presence and absence of visually guided behavior. Corticocortical interactions will be studied in three different behavioral contexts. 1) focused spatial attention; 2) selective feature attention; 3) perception of simultaneous contrast. Current models of cortical organization suggest that these behaviors should influence the interactions between disparate cortical areas. The timing and distribution of activity in the cortical laminae of V1 and V4 will be examined with multicontact electrodes in the anesthetized monkey. This study will resolve the role of descending projections from extrastriate cortex in the processing of visual form in area V1. The regional and laminar pattern of neurofibrillary tangles has led to the conclusion that the dementia associated with Alzheimer's disease is a consequence of a loss of corticocortical projections. The development of more accurate diagnostic techniques may well depend on a better understanding of the nature of corticocortical interactions in the primate brain.