TEMPORAL CODES AND CORTICOCORTICAL COMMUNICATION

拟议研究的主要目的是确定时间的作用， 皮质信息处理的密码当前型号的 平均放电率的符合检测和时间积分 直接用实验的方法来检验。 图案 识别和引导注意被选择为相关的皮层 可能选择不同处理的功能 战略布局 模式识别需要快速、并行和 在多个尺度内和跨多个尺度的多个特征的详尽绑定 很可能取决于在巧合中确定的快速定时方案 检测模型 另一方面，引导注意力反映了 一是信息渠道狭窄。 这个过程很可能 依赖于速度较慢的串行搜索方案， 编码策略，标记更高度活跃的神经亚群。 提出了具体的实验方法，以测试的利用率 清醒的动物神经元的这些策略参与了简单但 明确的行为任务。 这些研究的意义在于建立我们对 皮质动力学中时间处理的本质。知识 时间整合机制是下一个关键步骤， 研究脑损伤的各种问题越来越多的证据 指出时间处理的中断是 发展性和获得性认知障碍的潜在机制。 然而，基于模型的治疗方法的第一个提示， 时间处理表明，进一步详细了解 大脑皮层中信息流的时间安排将有助于 改善阅读障碍、头部创伤和中风患者的生活。 最终，大脑是由平行和垂直的 皮质下连接（边缘系统，纹状体，丘脑皮质）以及 这里强调的皮质联系。 建议的研究 将寻求框架的理解皮质皮质的相互作用， 这一背景将支持进一步研究丘脑皮质 一体化 从这一框架出发， 对治疗脑部疾病的意义范围。

The broad aim of the proposed studies is to define the role of temporal codes in corticocortical information processing. Current models of coincidence detection and temporal integration of average firing rates are directly examined with an experimental approach. Pattern recognition and directing attention are chosen as related cortical functions which are likely to select for different processing strategies. Pattern recognition which requires fast, parallel and exhaustive, binding of multiple features within and across many scales is likely to depend on the fast timing schemes identified in coincidence detection models. Directing attention, on the other hand, reflects the deploying of a narrow information channel. This process is likely to depend on slower, serial search schemes that are well supported by rate coding strategies that mark more highly active neural sub-populations. Specific experimental methods are proposed to test the utilization of these strategies by neurons in the awake animal engaged in simple but well-defined behavioral tasks. The significance of these studies is to build our understanding of the nature of temporal processing in cortical dynamics. Knowledge of the mechanisms of temporal integration is the next crucial step in approaching the varied problems of brain injury. Increasing evidence points to the disruption of temporal processing as a fundamental mechanism underlying developmental and acquired cognitive disabilities. Morever, the first hints of therapeutic approaches based on models of temporal processing suggest that further detailed knowledge of the timing of information flow in the cortex will assist the efforts to improve the lives of patients with dyslexia, head trauma and stroke. Ultimately, the brain is organized with parallel and vertical subcortical connections (limbic, striatal, thalamocortical) as well as the corticocortical connections emphasized here. The studies proposed will seek to frame the understanding of corticocortical interactions in a context that will support further studies of thalamocortical integration. Building out from this framework will enlarge the possible scope of significance for the treatment of brain disorders.