CORTICOCORTICAL INTERACTIONS IN VISION

视觉中的皮质相互作用

• 批准号: 2460452
• 负责人: Keith P. Purpura
• 金额: $ 7.13万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-04 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2460452
• 关键词: Macaca fascicularis; attention; brain electrical activity; brain mapping; cell cell interaction; visual cortex; visual pathways; visual stimulus

Corticocortical interactions in the primate visual system will be investigated to learn about the nature of the communication between cortical areas and how cortical regions interact in the analysis of the visual world. Paired electrophysiological recordings will be made between striate and extrastriate areas V1/V4, V1/IT and V4/IT in the awake-behaving monkey. Similar experiments will be performed in anesthetized monkeys. Visual stimuli will consist of both broadband and bandlimited noise as well as stimuli that allow for a separation of cortical feature extraction mechanisms from those of simple spatial filtering. Spike trains and local field potentials recorded in two visual areas will be analyzed for crosscorrelation structure in the presence and absence of visual stimuli and in the presence and absence of visually guided behavior. Corticocortical interactions will be studied in three different behavioral contexts. 1) focused spatial attention; 2) selective feature attention; 3) perception of simultaneous contrast. Current models of cortical organization suggest that these behaviors should influence the interactions between disparate cortical areas. The timing and distribution of activity in the cortical laminae of V1 and V4 will be examined with multicontact electrodes in the anesthetized monkey. This study will resolve the role of descending projections from extrastriate cortex in the processing of visual form in area V1. The regional and laminar pattern of neurofibrillary tangles has led to the conclusion that the dementia associated with Alzheimer's disease is a consequence of a loss of corticocortical projections. The development of more accurate diagnostic techniques may well depend on a better understanding of the nature of corticocortical interactions in the primate brain.

灵长类视觉系统中的皮质相互作用将是 调查以了解两国之间沟通的性质 大脑皮层区域以及大脑皮层区域如何相互作用 视觉世界。 成对的电生理记录将在纹状体和 清醒猴纹外区V1/V4、V1/IT和V4/IT。 类似的实验将在麻醉的猴子身上进行。视觉 刺激将包括宽带和带限噪声以及 允许分离皮质特征提取的刺激 与简单的空间滤波机制不同。尖峰列车和本地列车 将分析在两个可视区域中记录的场电位 视觉刺激存在和不存在时的互相关结构 以及在存在和不存在视觉引导行为的情况下。 皮质相互作用将在三种不同的行为中进行研究 上下文。1)聚焦空间注意；2)选择性特征注意；3) 同时对比度的感知。大脑皮层的当前模型 组织建议，这些行为应该影响 不同皮质区域之间的相互作用。 V1和V1皮质板层活动的时序和分布 V4将在麻醉状态下用多点接触电极检查 猴子。这项研究将解决下降投影的作用 V1区视觉形态加工中的纹外皮质。 神经原纤维缠结的局部和层状模式导致了 结论阿尔茨海默病相关痴呆是一种 皮质投射丢失的后果。的发展。 更准确的诊断技术很可能依赖于更好的 对灵长类皮质相互作用本质的理解 大脑。