HIP BONE DENSITY IN ELDERLY AFRICAN AMERICAN WOMEN

非洲裔美国老年女性的髋骨密度

• 批准号: 5215598
• 负责人: ARLINE DENISE BOHANNON
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5215598
• 关键词: African American; bone density; bone metabolism; clinical research; disease /disorder proneness /risk; female; gene frequency; hip; hip fractures; homeostasis; human old age (65+); human subject; osteoporosis; prognosis; racial /ethnic difference; vitamin D receptors

Osteoporosis and related fractures occur more frequently among Caucasian women than in African-American women. The incidence of hip fractures and other nonvertebral fractures among Caucasian women is twice that of African-American women. However the risk of hip fracture increases exponentially with age regardless of ethnicity. With the exception of increased age and low body mass index, little is known about risk factors for osteoporosis among African-American women and there is a scarcity of data concerning bone mineral metabolism of elderly African-American women in general. It is presumed that those lifestyle and dietary habits associated with osteoporosis in Caucasian women also apply to African-American women. The purpose of this study is to identify any racial differences in bone density, bone mineral metabolism, and vitamin D receptor allele frequencies among community dwelling elderly women (ages 70-80). One hundred women (half African American, half Caucasian) will be studied by measuring serum calcium, PTH metabolites, osteocalcin, and urinary hydroxyproline. These studies will allow us to assess bone turnover rate and mineral homeostasis. It is anticipated that after thorough characterization of metabolism in elderly African-American and Caucasian women, inferences can be drawn concerning predictors for their hip fracture risk. Studies have shown that although the incidence of hip fracture is decreased among African-American women compared with Caucasian women; those women that do sustain a fracture are more likely to have increased hospital mortality and disability following fracture when compared to Caucasian women. It is anticipated that the data and inferences drawn from this study will lead to an increased awareness of osteoporosis and its prevention among African-American women Also, after identifying African-American women at risk for osteoporosis and related fractures, this investigator plans an intervention study.

骨质疏松症和相关骨折在白种人中更常见 女性多于非洲裔美国女性。 髋部骨折的发生率和 白人女性的其他非椎骨骨折是白人女性的两倍 非裔美国女性。 然而髋部骨折的风险会增加 无论种族如何，随着年龄的增长呈指数增长。 除了 年龄增加和体重指数低，对危险因素知之甚少 非洲裔美国女性骨质疏松症的治疗方法匮乏 有关老年非洲裔美国女性骨矿物质代谢的数据 一般来说。 据推测，这些生活方式和饮食习惯 与白人女性骨质疏松症相关的也适用于 非裔美国女性。 本研究的目的是确定骨骼方面的种族差异 密度、骨矿物质代谢和维生素 D 受体等位基因 社区居住老年妇女（70-80 岁）的频率。 一 一百名女性（一半非裔美国人，一半白人）将被研究 测量血清钙、PTH 代谢物、骨钙素和尿钙 羟脯氨酸。这些研究将使我们能够评估骨转换率 和矿物质稳态。 预计经过彻底的 老年非洲裔美国人和白种人的代谢特征 对于女性，可以对其髋关节的预测因素做出推论 骨折风险。 研究表明，虽然髋部骨折的发生率 与白人女性相比，非裔美国女性的比例有所下降； 那些确实发生骨折的女性更有可能增加 与骨折后的医院死亡率和残疾相比 白人女性。 预计得出的数据和推论 这项研究将提高人们对骨质疏松症的认识 非洲裔美国妇女中的预防措施 非裔美国女性面临骨质疏松症和相关骨折的风险， 该研究者计划进行一项干预研究。