HIP BONE DENSITY IN ELDERLY AFRICAN AMERICAN WOMEN

本项目的目的是评估骨矿物质密度和骨 老年非裔美国妇女的矿物质稳态与年龄相比 匹配的白人女性 据估计，从这次彻底的 老年非裔美国妇女骨代谢的特征， 可以对他们髋部骨折风险的预测因素进行推断。 这项研究测量骨矿物质密度（股骨颈和腰椎） 和骨稳态的生化决定因素（钙、维生素D和 尿羟脯氨酸），69-79岁的流动妇女 岁，并进行种族比较。 样本量为100名女性（50 非裔美国人，50名白人）允许具有重要意义的权力 5%，以检测骨矿物质密度的0.5标准差， 赛马到目前为止，已经筛选了104名受试者参加 本研究78例受试者（51例白人，27例非裔美国人） 符合入选标准并已入组研究方案。 初步数据分析显示骨密度有增加的趋势 在非裔美国女性中，与高加索女性相比（平均髋部BMD g/cm 2非裔美国人- 0.8011 0.16，高加索人- 0.7411 0.13 p= 0.07）。 数据收集和受试者招募仍在进行中，完成 目前尚无法对结果进行统计分析。 数据收集和招募将继续达到样本量 100-123例受试者。 研究方案不会变更。 虽然非裔美国女性髋部骨折的发生率较低 比白人女性，非裔美国女性， 髋部骨折的死亡率和残疾率高于白人 妇女 关于非洲老年人的信息很少- 美国妇女与骨矿物质密度或骨折风险。 是 预计，关于非洲人髋部骨折风险的推断- 美国妇女可以在这项研究的结论。

The purpose of this project is to assess bone mineral density and bone mineral homeostasis in elderly African-American women as compared to age matched Caucasians women. It is anticipated that from this thorough characterization of bone metabolism in elderly African-American women, inferences can be made concerning predictors for their hip fracture risk. The study measures bone mineral density (femoral neck and lumbar spine) and biochemical determinants of bone homeostasis (calcium, vitamin D and urinary hydroxyproline) of community dwelling, ambulatory women ages 69-79 years old and makes racial comparisons. A sample size of 100 women (50 African-American, 50 Caucasian) allows for a power of with a significance of 5 % to detect a 0.5 standard deviation in bone mineral density between the races. To date 104 subjects have been screened for participation in this study. Seventy-eight subjects (51 Caucasian, 27 African-American) have met inclusion criteria and have been enrolled in the study protocol. Preliminary data analysis shows a trend of increased bone mineral density among African-American women as compared to Caucasian women (mean hip bmd g/cm2 African-American - 0.8011 0.16, Caucasian - 0.7411 0.13 p= 0.07). Data collection and subject recruitment are still in process, complete statistical analysis of the results are not available at this time. Data collection and recruitment will continue to achieve a sample size of 100-123 subjects. The study protocol will not be changed. Although the incidence of hip fracture is lower in African-American women than Caucasian women, African-American women that are hospitalized with hip fractures have increased mortality and disability than Caucasian women. There is little published information concerning elderly African- American women and bone mineral density or fracture risk. It is anticipated that inferences concerning hip fracture risk among African- American women can be drawn at the conclusion of this study.