HIP BONE DENSITY IN ELDERLY AFRICAN AMERICAN WOMEN

非洲裔美国老年女性的髋骨密度

• 批准号: 6243952
• 负责人: ARLINE DENISE BOHANNON
• 金额: $ 3.24万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-10-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6243952
• 关键词: African American; bone density; bone metabolism; caucasian American; clinical research; disease /disorder proneness /risk; female; hip; hip fractures; human old age (65+); human subject; racial /ethnic difference

The purpose of this project is to assess bone mineral density and bone mineral homeostasis in elderly African-American women as compared to age matched Caucasians women. It is anticipated that from this thorough characterization of bone metabolism in elderly African-American women, inferences can be made concerning predictors for their hip fracture risk. The study measures bone mineral density ( femoral neck and lumbar spine) and biochemical determinants of bone homeostasis ( calcium, vitamin D and urinary hydroxyproline) of community dwelling, ambulatory women ages 69-79 years old and makes racial comparisons. A sample size of 100 women (50 African-American, 50 Caucasian) allows for a power of with a significance of 5 % to detect a 0.5 standard deviation in bone mineral density between the races. To date 104 subjects have been screened for participation in this study. Seventy-eight subjects (51 Caucasian, 27 African-American) have met inclusion criteria and have been enrolled in the study protocol. Preliminary data analysis shows a trend of increased bone mineral density among African-American women as compared to Caucasian women (mean hip bmd g/cm2 African-American - 0.8011 0.16, Caucasian - 0.7411 0.13 p= 0.07). Data collection and subject recruitment are still in process, complete statistical analysis of the results are not available at this time. Data collection and recruitment will continue to achieve a sample size of 100-123 subjects. The study protocol will not be changed. Although the incidence of hip fracture is lower in African-American women than Caucasian women, African-American women that are hospitalized with hip fractures have increased mortality and disability than Caucasian women. There is little published information concerning elderly African-American women and bone mineral density or fracture risk. It is anticipated that inferences concerning hip fracture risk among African-American women can be drawn at the conclusion of this study.

本项目的目的是评估骨矿物质密度和骨 老年非裔美国妇女的矿物质稳态与年龄相比 匹配的白人女性。 据估计，从这次彻底的 老年非裔美国妇女骨代谢的特征， 可以推断出他们髋部骨折的预测因素 风险 这项研究测量了骨矿物质密度（股骨颈和腰椎）， 脊柱）和骨稳态的生化决定因素（钙， 维生素D和尿羟脯氨酸）的社区住宅，流动 年龄在69-79岁之间的女性，并进行种族比较。 样本量 100名女性（50名非洲裔美国人，50名白人）的权力， 具有5%的显著性，以检测骨中0.5的标准差 种族间的矿物质密度 到目前为止，已有104名受试者 筛选参与本研究的人。 78例受试者（51 高加索人，27名非洲裔美国人）符合入选标准， 已入组研究方案。 初步数据分析显示， 非洲裔美国妇女骨密度增加的趋势， 与白人女性相比（非裔美国人的平均髋部BMD g/cm 2， 0.8011 0.16，高加索人- 0.7411 0.13 p= 0.07）。 数据收集和 受试者招募仍在进行中，完成统计分析 目前还没有结果。数据收集和 招募将继续达到100-123名受试者的样本量。 研究方案不会变更。 虽然非裔美国人髋部骨折的发生率较低， 白人女性，非裔美国女性， 髋部骨折的死亡率和残疾率 白种女人 很少有公开的信息， 老年非裔美国妇女与骨密度或骨折 风险 预计有关髋部骨折风险的推断 在非洲裔美国妇女中， study.