HIP BONE DENSITY IN ELDERLY AFRICAN AMERICAN WOMEN

非洲裔美国老年女性的髋骨密度

• 批准号: 6273975
• 负责人: ARLINE DENISE BOHANNON
• 金额: $ 2.88万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6273975
• 关键词: African American; bone density; bone metabolism; calcium; caucasian American; clinical research; clinical trials; disease /disorder proneness /risk; female; hip fractures; human old age (65+); human subject; hydroxyproline; racial /ethnic difference; vitamin D; women's health

The purpose of this project is to assess bone mineral density and bone mineral homeostasis in elderly African-American women as compared to age matched Caucasians women. It is anticipated that from this thorough characterization of bone metabolism in elderly African-American women, inferences can be made concerning predictors for their hip fracture risk. The study measures bone mineral density (femoral neck and lumbar spine) and biochemical determinants of bone homeostasis (calcium, vitamin D and urinary hydroxyproline) of community dwelling, ambulatory women ages 69-79 years old and makes racial comparisons. A sample size of 100 women (50 African-American, 50 Caucasian) allows for a power of with a significance of 5 % to detect a 0.5 standard deviation in bone mineral density between the races. To date 104 subjects have been screened for participation in this study. Seventy-eight subjects (51 Caucasian, 27 African-American) have met inclusion criteria and have been enrolled in the study protocol. Preliminary data analysis shows a trend of increased bone mineral density among African-American women as compared to Caucasian women (mean hip bmd g/cm2 African-American - 0.8011 0.16, Caucasian - 0.7411 0.13 p= 0.07). Data collection and subject recruitment are still in process, complete statistical analysis of the results are not available at this time. Data collection and recruitment will continue to achieve a sample size of 100-123 subjects. The study protocol will not be changed. Although the incidence of hip fracture is lower in African-American women than Caucasian women, African-American women that are hospitalized with hip fractures have increased mortality and disability than Caucasian women. There is little published information concerning elderly African- American women and bone mineral density or fracture risk. It is anticipated that inferences concerning hip fracture risk among African- American women can be drawn at the conclusion of this study.

该项目的目的是评估骨密度和骨。 老年非裔美国女性矿物质稳态与年龄的比较 与高加索女性相匹配。预计从这次彻底的 老年非裔美国妇女的骨代谢特征， 可以对他们髋部骨折风险的预测因素做出推断。 这项研究测量了骨密度(股骨颈和腰椎) 和骨骼稳态的生化决定因素(钙、维生素D和 69-79岁社区居留、流动妇女尿羟脯氨酸 几岁，并进行种族比较。样本大小为100名女性(50名 非洲裔美国人，50%的高加索人)允许一种具有重要意义的力量 5%来检测骨密度之间的0.5标准差 比赛。到目前为止，已对104名受试者进行了参与 这项研究。78名受试者(51名高加索人，27名非裔美国人) 已达到纳入标准，并已加入研究方案。 初步数据分析显示骨密度有增加的趋势 非裔美国女性与高加索女性的对比(平均髋部骨密度 非裔美国人-0.8011.16，高加索人-0.7411.13(p=0.0 7)。 数据收集和受试者招募仍在进行中，完成 目前尚不能对结果进行统计分析。 数据收集和招聘将继续实现样本规模为 100-123名受试者。研究方案不会改变。 尽管非裔美国女性髋部骨折的发生率较低 而不是高加索女性，非裔美国女性 髋部骨折比高加索人的死亡率和致残率更高 女人。关于非洲老年人的公开信息很少- 美国女性与骨密度或骨折风险有关。它是 预计有关非洲人髋部骨折风险的推论- 这项研究的结论可以得出美国女性的结论。