OUTPATIENT TREATMENT--TARGETED VS MAINTENANCE MEDICATION
OUTPATIENT TREATMENT--TARGETED VS MAINTENANCE MEDICATION
批准号:
2244457
负责人:
William T. Carpenter
金额:
$36.08万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-09-01 至 1997-08-31
中文摘要
在这个项目的前五年,我们比较了
英文摘要
During the first five years of this project, we compared the
efficacy of a targeted, early intervention strategy using
neuroleptic medication with a strategy using early intervention
(increased dosage) that supplemented ongoing maintenance
neuroleptic therapy. Our experience to date is useful for the
work proposed in the current application in several ways. First,
we have developed a rapid, effective pharmacologic intervention
at relapse for patients assigned to either drug-free or
experimental drug status. Since targeted, early intervention
treatment efforts are feasible and effective, the consequences of
ineffective experimental or placebo treatment need not be severe
deterioration in clinical state. Second, our experience with the
early intervention, targeted neuroleptic strategy suggests the
likelihood that highly sensitive detection of a prodromal syndrome
includes symptoms that are false-positive with respect to relapse
and often includes psychopathology likely to be susceptible to
anxiolytic drug treatment. Third, we now have a trained and
experienced clinical staff with established competence in dealing
with chronically and severely mentally ill patients within the
protocol demands of controlled clinical studies. Fourth, we have
gained the logistical experience necessary for conducting
outpatient clinical trials.
As originally described, the specific aims of the project were to
determine the relative effectiveness of two pharmacotherapeutic
approaches to the care of schizophrenic outpatients, one involving
the targeted use of neuroleptic drugs for symptom exacerbation
and the other involving the use of these same drugs for
maintenance purposes. At the outset, the feasibility and ethics of
the noncontinuous targeted approach were heatedly debated;
however, the potential advantages of this alternative strategy for
the actively noncompliant patient were compelling, and there was
a growing appreciation that placebo controlled continuous drug
trials had not addressed the central hypothesis of this project.
The possibility that this approach would be a feasible alternative
for a substantial proportion of schizophrenic patients was
sufficiently attractive to merit empirical evaluation in a random
assignment, comparative treatment study.
The immediate goal was to ascertain if a substantial reduction in
the use of neuroleptic drugs could be achieved without adversely
affecting course and outcome status as reflected in symptomatic
clinical decompensation and the need for hospital care.
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A 3T Scanner for Establishing UM MPRC Neuroimaging Research Facility
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批准号:7842843
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项目类别:
-
资助金额:$283.05万
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财政年份:2010
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负责人:William T. Carpenter
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依托单位:
Center for Intervention Development and Applied Research
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批准号:7812750
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项目类别:
-
资助金额:$9.17万
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财政年份:2009
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负责人:William T. Carpenter
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依托单位:
Centers for Intervention Development and Applied Research (CIDAR)
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批准号:8080317
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项目类别:
-
资助金额:$186.67万
-
财政年份:2008
-
负责人:William T. Carpenter
-
依托单位:
Centers for Intervention Development and Applied Research (CIDAR)
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批准号:8327303
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项目类别:
-
资助金额:$179.77万
-
财政年份:2008
-
负责人:William T. Carpenter
-
依托单位:
Centers for Intervention Development and Applied Research (CIDAR)
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批准号:7690198
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项目类别:
-
资助金额:$199.82万
-
财政年份:2008
-
负责人:William T. Carpenter
-
依托单位:
Centers for Intervention Development and Applied Research (CIDAR)
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批准号:7450397
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项目类别:
-
资助金额:$199.99万
-
财政年份:2008
-
负责人:William T. Carpenter
-
依托单位:
Centers for Intervention Development and Applied Research (CIDAR)
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批准号:7892530
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项目类别:
-
资助金额:$195.42万
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财政年份:2008
-
负责人:William T. Carpenter
-
依托单位:
CORE--RESEARCH METHODS CORE
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批准号:7553490
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项目类别:
-
资助金额:$12.88万
-
财政年份:2007
-
负责人:William T. Carpenter
-
依托单位:
Bios. and Data Man.
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批准号:7553493
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项目类别:
-
资助金额:$48.2万
-
财政年份:2007
-
负责人:William T. Carpenter
-
依托单位:
CORE--PRINCIPAL RESEARCH CORE
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批准号:7553491
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项目类别:
-
资助金额:$13.9万
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财政年份:2007
-
负责人:William T. Carpenter
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依托单位:
CORE--OPERATIONS CORE
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批准号:7553489
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项目类别:
-
资助金额:$25.56万
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财政年份:2007
-
负责人:William T. Carpenter
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依托单位:
GLUTAMATERGIC AGENTS FOR THE TREATMENT OF NEGATIVE SYMPTOMS
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批准号:7203278
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项目类别:
-
资助金额:$0.89万
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财政年份:2005
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负责人:William T. Carpenter
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依托单位:
Multidisciplinary Schizophrenia Research Training
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批准号:10400081
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项目类别:
-
资助金额:$4.02万
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财政年份:2004
-
负责人:William T. Carpenter
-
依托单位:
Multidisciplinary Schizophrenia Research Training
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批准号:7074027
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项目类别:
-
资助金额:$26.82万
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财政年份:2004
-
负责人:William T. Carpenter
-
依托单位:
Multidisciplinary Schizophrenia Research Training
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批准号:10206966
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项目类别:
-
资助金额:$2.08万
-
财政年份:2004
-
负责人:William T. Carpenter
-
依托单位:
Multidisciplinary Schizophrenia Research Training
-
批准号:6876089
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项目类别:
-
资助金额:$27.58万
-
财政年份:2004
-
负责人:William T. Carpenter
-
依托单位:
Multidisciplinary Schizophrenia Research Training
-
批准号:7496574
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项目类别:
-
资助金额:$19.78万
-
财政年份:2004
-
负责人:William T. Carpenter
-
依托单位:
Multidisciplinary Schizophrenia Research Training
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批准号:8669163
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项目类别:
-
资助金额:$29.58万
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财政年份:2004
-
负责人:William T. Carpenter
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依托单位:
Multidisciplinary Schizophrenia Research Training
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批准号:7266970
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项目类别:
-
资助金额:$26.82万
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财政年份:2004
-
负责人:William T. Carpenter
-
依托单位:
Multidisciplinary Schizophrenia Research Training
-
批准号:10620156
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项目类别:
-
资助金额:$11.15万
-
财政年份:2004
-
负责人:William T. Carpenter
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依托单位:
海外基金