PEDIATRIC AIDS CLINICAL TRIALS GROUP

我们建议在纽约市建立纽约儿科 上西区艾滋病临床试验单位联盟。本财团 由以下网站组成：婴儿医院、哈莱姆医院、 化身儿童中心(ICC)和圣卢克·罗斯福 医院。该联盟位于艾滋病毒的震中 流行病，因此可以向100多个人提供对ACTG协议的访问 每年新增感染艾滋病毒的妇女、婴儿和儿童。个人资料调查及 每个机构的其他研究人员都是经验丰富的研究人员 艾滋病临床试验，每个人都是 哥伦比亚大学内科和外科医生学院。他们提供了 天赋和兴趣的激动人心的组合，因为有些是 儿科传染病专科医生和其他专家是主要的 护理医生。不仅有ACTG认证的免疫学和 所有样本都将被送往婴儿病毒学实验室，但 还有一批老牌的和独立资助的 对艾滋病毒基础研究感兴趣的调查人员，谁将 为方法上的新想法的发展提供临界质量 预防和治疗艾滋病毒感染。在婴儿医院 参与美国国立卫生研究院支持的艾滋病毒病毒研究的工作人员相互交织 女性向子代的传播(WITS)和ACTG临床 试验提供了一个独特的机会，患者从一个 将艾滋病毒研究转化为另一种，从而导致获得高水平的 ACTU协议中的妇女和儿童。有代表性的病人 该联盟的医院所服务的人口主要是 贫困、来自少数群体和社会弱势群体。这 受艾滋病疫情影响最大的是人口。访问高度 婴儿医院的专门三级护理设施提供 为其他机构提供大量艾滋病毒感染者的动力 妇女和儿童将与婴儿医院一起创建 财团。在过去的一年里，婴儿网站和国际刑事法院的工作人员 已经协同工作，招收了大量的 患者进入ACTU方案(儿科ACTG第二个四分位数 1992年招生人数)。该财团的成立将提供 更好地接触患者，卓越的医疗水平 基础研究人员与学术人员的能力和互动 从事ACTG临床试验的医生，这应该导致 在预防和预防方面的研究具有很高的生产力 艾滋病毒感染的治疗。

We propose to establish, in New York City, The New York Pediatric Upper West Side AIDS Clinical Trials Unit Consortium. This Consortium is composed of the following sites: Babies Hospital, Harlem Hospital, Incarnation Children's Center (ICC), and St. Luke's Roosevelt Hospital. The Consortium is located in an epicenter of the HIV epidemic, and as such can provide access to ACTG protocols to over 100 new HIV-infected women, infants, and children per year. The PIs and other researchers at each institution are seasoned investigators in AIDS clinical trials, and each is a full time faculty member at the Columbia University College of Physicians and Surgeons. They provide a stimulating mix of talent and interests, in that some are specialists in Pediatric Infectious Diseases and others are Primary Care Physicians. There is not only an ACTG-certified immunology and virology laboratory at Babies to which all specimens will be sent, but there are also a group of established and independently funded investigators with interests in basic research on HIV, who will provide a critical mass for the development of new ideas in approaches to prevent and treat HIV infections. At Babies Hospital the interweaving of staff involved in NIH-supported HIV studies of viral transmission from women to their offspring (WITS) and in ACTG clinical trials provides a unique opportunity for rollover of patients from one HIV study into another, thus resulting in a high level of access to women and children in ACTU protocols. The representative patient population served by the hospitals of the Consortium is largely impoverished, from minority groups, and socially disadvantaged. This population is hardest hit by the AIDS epidemic. Access to highly specialized tertiary care facilities at Babies Hospital provides an impetus for the other institutions with large numbers of HIV-infected women and children to join with Babies Hospital to create the Consortium. For the past year, staff at the Babies site and at ICC have worked together synergistically to enroll a large number of patients into ACTU protocols (2nd quartile in Pediatric ACTG enrollment for 1992). Formation of the Consortium will provide greater access to patients, an outstanding level of medical competence, and interaction of basic researchers with academic physicians engaged in ACTG clinical trials, which should lead to a high degree of productivity in research on the prevention and treatment of HIV infection.