EXPANSION AND INCREASED EFFICIENCY OF ANIMAL FACILITY

印第安纳大学所有涉及使用实验室动物的研究 大学牙科学院在其位于内部的， 印第安纳波利斯校区AAALAC认可的动物研究设施和 获得类似认证的卫星设施(实验动物资源) 布鲁明顿校区。满足日益增长的实验室需求 牙科学院的研究人员使用动物，这项建议 旨在支持翻新，以扩大内部的可用空间 这两个设施和提高空间的利用效率 通过建造层流气流保持架。此外, 主要支持设备(包括高压灭菌器、自动洗衣机、 需要用于合成饲料的搅拌器和电子动物天平) 对设施内现有的设备进行升级。 这项建议的具体目的是：(1)提供两个额外的 鼠房和大型狗的六个跑道；(2)提供 每个设施一个研究支持室和一个储藏室；(3)升级 通过翻新9个房间的地板来改造现有的动物房间；(4)改善 安装通风装置对新建鼠房的使用效果 笼子单位；(5)通过以下方式提高维持卫生标准的能力 购买高压锅和洗瓶机；以及(6)提高产品质量 通过购买饮食搅拌器和电子动物提供研究支持 平衡。这些翻新和收购将使我们能够提供 为安置调查人员所需的所有动物和 遵守卫生标准和所有其他规定 关于在研究中照顾和使用动物的问题。

All research involving the use of laboratory animals at the Indiana University School of dentistry is conducted within its internally-located, AAALAC-accredited Animal Research Facility on the Indianapolis campus and a similarly-accredited satellite facility (Laboratory Animal Resources) on the Bloomington campus. To meet the increased demands for Laboratory animal use by investigators within the School of Dentistry, this proposal is designed to support renovations to expand the available space within these two facilities and to improve the efficiency of utilizing the space through the construction of laminar air-flow caging units. In addition, major support equipment (including an autoclave, an automatic washer, a mixer for synthetic diets and an electronic animal balance) is requested to upgrade the equipment available within the Facility. The Specific Aims of this proposal are to: (1) provide two additional rooms for housing rodents and six runs for housing large dogs; (2) provide a research support room plus a storage room in each facility; (3) upgrade existing animal rooms by refinishing the floors in nine rooms; (4) improve efficiency of utilizing the new rodent rooms by installing ventilated Caging units; (5) improve ability to maintain sanitation standards by purchasing an autoclave and bottle washer; and (6) improve the quality of research support by purchasing a diet mixer and an electronic animal balance. These renovations and acquisitions will allow us to provide the necessary space for housing all the animals required by investigators and to comply with sanitation standards as well as all other regulations regarding the care and use of animals in research.