Development of QLF Handpiece for Early Caries Detection

开发用于早期龋齿检测的 QLF 手机

• 批准号: 6993239
• 负责人: George K Stookey
• 金额: $ 34.18万
• 依托单位: THERAMETRIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-08 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6993239
• 关键词: adolescence (12-20); bioengineering /biomedical engineering; clinical biomedical equipment; clinical research; computer program /software; computer system design /evaluation; data collection methodology /evaluation; dental caries; dental disorder diagnosis; dental visualization; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder proneness /risk; early diagnosis; ergonomics; fluorescence; human subject; image enhancement; middle childhood (6-11); oral health; orthodontics; patient oriented research; portable biomedical equipment; tooth enamel

DESCRIPTION (provided by applicant): During the past 40 years there has been a remarkable decline in the prevalence of dental caries due to the widespread use of fluoride in public health programs, such as communal water fluoridation, dental practice and in oral hygiene products. In spite of this, dental caries continues to be the most prevalent dental disease. It is known that the traditional visual-tactile clinical caries examination procedure cannot detect lesions until they advance to the stage where they are difficult to reverse with fluorides and other measures. The understanding of the caries process has progressed far beyond the point of restricting the evidence for dental caries at the E2 (caries in enamel only) or D3 (caries in enamel and dentin) levels of cavitations. Recording lesions only at the cavitation level is no longer acceptable (ICCCT, 2002). Quantitative Light Fluorescence (QLF) is a technology that has been shown to detect and quantify the progress of lesions at an early stage (pre-cavitation). This technology will allow dental practitioners to: (a) identify early enamel demineralization reflecting caries risk prior to cavitation; (b) implement appropriate interventions to reverse the disease process at an earlier stage with more efficient outcomes; and (c) monitor the success or failure of the applied intervention measures. The overall goal of this program is to develop a QLF research system for use in clinical dental practice. The Phase I program successfully overcame the limitations of a research hand-piece to permit routine clinical use. The Phase 2 program seeks to further refine the instrument hardware and user software to make the technique practical within clinical practice. The specific aims of this application are to: (1) refine the instrument to make it more ergonomic and facilitate practical infection control procedures; (2) verify the ability of the redesigned instrument to detect early caries and monitor changes in a laboratory; (3) develop user-friendly computer software interfaces that are compatible with the existing software for use by dental professionals; (4) develop appropriate training materials; (5) verify efficacy of the system through a clinical investigation. The results of this research should improve dental health of the general population by identifying dental patients at greater risk of developing dental caries and result in the implementation of interventions to reverse the process and reduce or prevent the need for restorations.

描述（由申请人提供）：在过去的40年中，由于氟化物在公共卫生项目中的广泛使用，如公共饮水氟化、牙科实践和口腔卫生产品，龋齿的患病率显著下降。尽管如此，龋齿仍然是最普遍的牙科疾病。众所周知，传统的视觉-触觉临床龋齿检查程序不能检测到病变，直到病变进展到难以用氟化物和其他措施逆转的阶段。对龋齿过程的理解已经远远超出了将龋齿的证据限制在E2（仅牙釉质中的龋齿）或D3（牙釉质和牙本质中的龋齿）空化水平的程度。仅在空化水平记录病变不再被接受（ICCCT，2002）。定量光荧光（QLF）是一种已被证明可以在早期阶段（空化前）检测和量化病变进展的技术。这项技术将使牙科医生能够：（a）在空化之前识别反映龋齿风险的早期釉质脱矿;（B）实施适当的干预措施，以在早期阶段扭转疾病过程，取得更有效的结果;（c）监测所采用的干预措施的成败。该计划的总体目标是开发一个用于临床牙科实践的QLF研究系统。I期项目成功克服了研究手柄的局限性，允许常规临床使用。第2阶段计划旨在进一步完善仪器硬件和用户软件，使该技术在临床实践中实用。本申请的具体目的是：（1）改进仪器，使其更符合人体工程学，并促进实际的感染控制程序;（2）验证重新设计的仪器在实验室中检测早期龋齿和监测变化的能力;（3）开发与牙科专业人员使用的现有软件兼容的用户友好的计算机软件界面;（4）开发适当的培训材料;（5）通过临床调查验证系统的有效性。这项研究的结果应通过识别患龋齿风险更大的牙科患者来改善普通人群的牙齿健康，并导致实施干预措施，以扭转这一过程，减少或防止对龋齿的需求。