IMPACT OF MALNUTRITION ON FLUORIDE PHARMACOLOGY

营养不良对氟化物药理学的影响

• 批准号: 6238490
• 负责人: George K Stookey
• 金额: $ 0.13万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6238490
• 关键词: China; Ecuador; air pollution; blood chemistry; dental caries; dental pharmacology; environmental toxicology; epidemiology; fluorine; fluorosis; genetic crossing over; human population study; human subject; hypocalcemia; malnutrition; nutrition related tag; pharmacokinetics; protein deficiency; public health; urinalysis; water supply

The cariostatic efficacy of fluoride present in communal water supplies is well-known and has resulted in the widespread use of fluoride in this manner, as well as in a variety of other delivery systems, for the prevention of dental caries. It is also known that the ingestion of excessive amounts of fluoride during the childhood period of tooth formation may result in the development of dental fluorosis. Additional reports have indicated that the presence of nutritional inadequacies serves to increase both the prevalence and severity of dental fluorosis and may also contribute to the development of skeletal fluorosis. However, virtually no information exists from human studies regarding the impact of nutritional inadequacies on any other possible pharmacologic or genotoxic effects of fluoride. In view of the widespread use of fluoride as well as the existence of nutritional inadequacies throughout the world, additional information is needed to permit and assure the safe public health use of fluoride for caries prevention. The long-term objective of this investigation is to provide necessary information to permit and assure the safe public health use of fluoride to prevent caries. The specific objectives of this investigation are to determine: (1) the relationship between chronic nutritional inadequacies and the prevalence/severity of dental and skeletal fluorosis associated with excessive fluoride ingestion; and (2) if nutritional inadequacies exacerbate any pharmacologic or genotoxic effects of fluoride in persons having chronic, excessive fluoride exposure. The investigation will involve population groups in The People's Republic of China and in Ecuador who have various combinations of nutritional inadequacies and fluoride exposure of varying degrees from either drinking water or ambient air. Collected data will include dental fluorosis and caries prevalence, nutritional status, skeletal fluorosis, fluoride content of urine and blood, and extensive chemical, electrolyte, and lymphocyte SCE assays of blood. The results of these studies will be useful in developing or refining current guidelines regarding the safe public health use of fluoride.

公共供水中存在的氟化物的防龋性是 众所周知，并导致氟化物在这一领域的广泛使用 方式，以及在各种其他交付系统中，用于 预防龋齿。还有一点是已知的，摄入 儿童时期牙齿氟化物超标 氟的形成可能导致氟斑牙的发生。其他内容 报告表明，营养不足的存在有助于 增加氟斑牙的患病率和严重程度，并可能 也会导致氟骨症的发生。然而， 几乎没有来自人类研究的信息关于 任何其他可能的药物或基因毒性的营养不足 氟化物的影响。鉴于氟化物的广泛使用以及 世界各地都存在营养不足，此外 需要信息来允许和确保安全的公共卫生使用 预防龋齿的氟化物。 这项调查的长期目标是提供必要的 允许和确保安全公共卫生地使用氟化物的信息 预防龋齿。这项调查的具体目标是 确定：(1)慢性营养不足之间的关系 以及相关的氟斑牙和氟骨症的患病率/严重程度 摄氟量过大；以及(2)如果营养不足 加剧氟化物对人体的任何药理或遗传毒性作用 长期过量接触氟化物。调查将会进行 让中国共和国和厄瓜多尔的人口群体参与进来 他们有营养不足和氟化物的各种组合 不同程度的暴露于饮用水或环境空气中。 收集的数据将包括氟牙症和龋齿患病率， 营养状况、氟骨症、尿氟含量和 血液，以及广泛的化学、电解质和淋巴细胞姐妹染色单体交换分析 血。这些研究的结果将有助于制定或 完善关于安全公共卫生使用的现行指南 氟化物。