PHARMACOLOGICAL EFFECTS OF FLUORIDE

公共卫生用水中氟化物的使用情况 预防龋齿是全世界公认的安全有效的方法 以这种方式在痕量浓缩物中的使用已被反复 有记录在案。已证实的氟化物的防腐活性导致了 含氟产品的广泛使用进一步和这 随着氟化物使用量的增加，问题也就不足为奇了 关于这种毒剂的安全性的问题继续被提出。 该计划项目的总体目标是开发其他 确保继续安全使用氟化物的科学信息 牙科公共卫生。该计划涉及三个项目，其中 由三个核心单位提供适当的行政支持， 生物统计学和实验室分析。项目1旨在 研究氟化物可能的药理和遗传毒性作用 与终生摄取最佳或较高水平的 饮用水中的氟化物，医学上摄入氟化物的影响- 患有糖尿病或慢性肾脏疾病的儿童和成人 失败，以及大剂量氟化物用于治疗的影响 骨质疏松。项目2利用受控动物模型研究 各种医学危害条件的影响(即，老化， 糖尿病、肾功能衰竭和营养不良)对药物的影响 氟化物。项目4将调查慢性营养不良的影响 氟化物在人群中药理作用的不足 居住在中国人民共和国和厄瓜多尔的团体。

The public health use of fluoride in communal water supplies for the prevention of dental caries is accepted worldwide and the safety efficacy of its use in trace concentrations in this manner have been repeatedly documented. The proven cariostatic activity of fluoride has resulted in the widespread of fluoride-containing products to further and this increasing use of fluoride, it is not surprisingly that questions pertaining to the safety of this agent continue to be raised. The overall goal of this Program Project is to develop additional scientific information to assure the continued safe use of fluoride for dental public health. The Program involves three projects with the appropriate support provided by three core units for administration, biostatistics, and laboratory analyses. Project #1 is designed to investigate the possible pharmacologic and genotoxic effects of fluoride associated with lifetime ingestion of optimal or elevated levels of fluoride in the drinking water, effects of fluoride ingestion in medically- compromised children and adults afflicted with diabetes or chronic renal failure, and the effects of massive dosages of fluoride used to treat osteoporosis. Project #2 utilizes controlled animal models to investigate the impact of various medically-compromising conditions (i.e., aging, diabetes, renal failure and malnutrition) upon the pharmologic effects of fluoride. Project #4 will investigate the effect of chronic nutritional inadequacies upon the pharmacologic effects of fluoride in population groups residing The Peoples Republic of China and in Ecuador.