EPIDEMIOLOGY OF CAROTID ARTERY ATHEROSCLEROSIS IN YOUTH

青年颈动脉粥样硬化的流行病学

• 批准号: 2771447
• 负责人: RONALD M LAUER
• 金额: $ 14.82万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2771447
• 关键词: angiocardioultrasonography; apolipoproteins; atherosclerosis; blood glucose; blood lipoprotein; blood pressure; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; carotid artery; child (0-11); cholesterol; disease /disorder proneness /risk; family genetics; genotype; human mortality; human subject; insulin; longitudinal human study; smoking; young adult human (21-34)

DESCRIPTION: (Adapted from Investigator's Abstract) The atherosclerotic process begins in childhood and advances through adult life when occlusive vascular disease results in coronary heart disease, stroke and peripheral vascular disease. Although risk factors have been established in adult populations, risk factors when measured in childhood have not been directly related to morbidity and mortality from occlusive atherosclerotic disease. The ultrasonographic measurement of carotid artery intimal-medial thickness (IMT) in adults is related not only to the risk for stroke but also to the severity of atherosclerotic disease in the coronary arteries. In 1970, a population of school age children and adolescents was first examined in Muscatine, Iowa, and since then has been followed to examine the predictive value of childhood risk factor levels for cardiovascular disease. A sample of this longitudinal cohort, with risk factors measured at least twice during childhood and once during adult life, is available for study. It is representative of the initial population, which presently ranges in age from 31 to 40 years, and lives in the Muscatine area. The investigators note that this cohort provides an opportunity to examine the relationship of risk factors measured in childhood to IMT in early adulthood and to examine familial factors which may be related to increased IMT. In this application, the investigators describe a study to examine the following: 1) the relationship of body mass index (BMI), blood pressure, total cholesterol, and smoking behaviors measured in childhood to IMT measured in early adulthood; 2) the relationship of risk factors (BMI, blood pressure, total cholesterol, LDL-C, HDL-C, Apo A1, Apo B, Lp(a), Apo E genotypes, glucose insulin and smoking) to IMT in young adults; 3) the relationship of risk factor 'load' from childhood to adult life to IMT; 4) the relationship of IMT in young adults to familial mortality in first- and second-degree relatives due to vascular disease; and 5) the degree of familial aggregation of IMT in young adults and their parents. The investigators believe this study will provide a view of the significance of IMT in young adults not only in its relationship to risk factors in childhood and young adulthood but also to familial factors that may be responsible for accelerated atherosclerosis.

描述：（改编自研究者摘要）动脉粥样硬化 这一过程始于童年，并在成年后继续发展， 闭塞性血管疾病导致冠心病、中风和 外周血管疾病尽管风险因素 在成年人群中建立，当测量 儿童期与发病率和死亡率没有直接关系， 闭塞性动脉粥样硬化疾病超声测量 成人颈动脉内膜-中层厚度（IMT）与颈动脉内膜-中层厚度（IMT）之间无相关性。 不仅与中风的风险有关， 冠状动脉疾病。1970年，学龄人口 儿童和青少年首先在爱荷华州的马斯卡廷进行了检查， 从那时起，一直在研究童年的预测价值， 心血管疾病的危险因素水平。一个样本 纵向队列，期间至少测量两次风险因素 童年和一次在成年生活中，可供研究。是 代表了最初的人口，目前的年龄范围 年龄在31到40岁之间，住在马斯卡廷地区。调查人员 请注意，这一队列提供了一个机会，以检查关系， 从儿童期测量的风险因素到成年早期的IMT， 检查可能与IMT增加相关的家族因素。 在本申请中，研究人员描述了一项研究， 以下内容：1）体重指数（BMI）、血压、 总胆固醇和吸烟行为对IMT的影响 在成年早期测量; 2）风险因素（BMI， 血压、总胆固醇、LDL-C、HDL-C、Apo A1、Apo B、Lp（a）， 载脂蛋白E基因型、血糖、胰岛素、吸烟等因素对青年人IMT的影响; 3)儿童期至成年期危险因素“负荷”关系 4）青壮年IMT与家族死亡率的关系 在一级和二级亲属中，由于血管疾病;以及5） 年轻人及其父母IMT的家族聚集性程度。 研究人员认为，这项研究将提供一个观点， IMT在年轻人中意义不仅在于其与风险的关系， 童年和青年时期的因素以及家庭因素 可能是加速动脉粥样硬化的原因