AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY

我们建议进行一项为期四年的前瞻性社区研究。 旨在发现其特征的记忆损伤(AAMI)， 患病率、发病率和临床意义。1000名受试者将 是从1,250名目前参加 心血管健康研究，其中包含大量的人口统计学和医学数据 正在被收集。诊断将在以下基础上做出 神经心理测试、主观报告和访谈。两个级别的 急性心肌梗死将被区分为：第一，记忆力的适龄下降 从推定的最佳青年水平来看，预计将出现在 25%-65%的人口。第二，更深刻的下降，具体到 并导致内存测试性能受损，即使在 与他们的同龄人相比，将不会很常见(可能 5-10%)。它们在多大程度上代表了定性上的不同 将考虑实体，而不是不同程度的减值。 非典型形式可能是即将到来的 将对痴呆症进行调查。评估将在18个月后重复进行 (在第三年)为了发现AAMI的进步程度，它是如何 进展和现在寻找事件案例。两国之间的关系 急性心肌梗死、心血管疾病、抑郁症和其他形式的共病 将会被检查。 另外两项涉及AAMI样本小子集的研究将是 融入核心工程。一个将是认知型的 记忆受损受试者的神经心理学研究旨在发现 急性心肌梗死患者的记忆损害在多大程度上与其相似 这一点见于痴呆症。另一项子研究将是一项治疗试验 调查在使用外部记忆方面的培训程度 艾滋病和其他补偿技术可以减少急性心肌梗死对 日常生活。

We propose a four year prospective, community-based study of Age Associated Memory Impairment (AAMI) designed to discover its characteristics, prevalence, incidence, and clinical significance. The 1,000 subjects will be drawn from a sample of 1,250 elderly adults currently participating in a cardiovascular health study in which extensive demographic and medical data are being collected. Diagnosis will be made on the basis of neuropsychological testing, subjective report and interview. Two levels of AAMI will be distinguished: The first, an age-appropriate decline in memory from presumed optimum young adult levels, is expected to be present in 25-65% of the population. The second, a more profound decline specific to memory and resulting in memory test performance which is impaired even when compared with that of their age-peers, will be much less common (probably 5-10%). The extent to which these represent qualitatively distinct entities, rather than different degrees of impairment, will be considered. The possibility that the atypical form is the forerunner of an impending dementia will be investigated. Evaluations will be repeated after 18 months (in year three) to discover the extent to which AAMI is progressive, how it progresses and to look for now incident cases. The relationship between AAMI, cardiovascular disease, depression and other forms of comorbidity will be examined. Two additional studies involving small subsets of the AAMI sample will be integrated into the core project. One will be a cognitive neuropsychological study of memory impaired subjects designed to discover the extent to which the memory impairment of AAMI qualitatively resembles that seen in dementia. The other substudy will be a treatment trial investigating the extent to which training in the use of external memory aids, and other compensatory techniques can reduce the impact of AAMI on daily life.