PLANUM TEMPORALE IN SCHIZOPHRENIA

精神分裂症的颞平面

• 批准号: 2250222
• 负责人: PATRICK E BARTA
• 金额: $ 10.92万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2250222
• 关键词: age difference; cerebral dominance; gender difference; human subject; image processing; magnetic resonance imaging; neuroanatomy; phantom model; psychobiology; schizophrenia; socioeconomics; temporal lobe /cortex

The human brain is laterally asymmetric. Although anatomic structures on the left tend to resemble their homologous structure on the right, there are consistent and functionally important differences between them, particularly in the posterior temporal lobe areas involved in language processing. Postmortem and in-vitro imaging studies have reported several consistent left-right differences. The planum temporal (PT) is, on the average, larger on the left than the right. This surface is intimately related to Wernicke's region in the left posterior temporal lobe. Yet, because previous investigators used varying anatomical criteria for PT and different methods for measuring it, comparison between studies proves difficult,and no prior method seems ideal. Previous work suggests that the normal asymmetry of the PT may be altered in some schizophrenic patients' brains. There is increasing evidence that some cardinal symptoms of schizophrenia (hallucinations and though disorder) are associated with changes in the left temporal lobe, suggesting that the PT's changes may be related to schizophrenic symptoms. The proposed study aims to compare the contrast new and old MRI measures of the PT in normals. A second goal is to apply these measurements to the PTs of schizophrenic patients and carefully matched controls. Finally, based on previous findings, we hypothesize that the degrees of left-right asymmetry of the PT is likely to correlate with specified positive symptoms of schizophrenia. If this is true, it would further the understanding of the biological basis of the disorder, provide a possible marker for an identifiable subgroup of schizophrenia (which is probably a heterogeneous disorder), and suggest some connection between these symptoms and several other active areas within neuroscience research, particularly the study of language, gender differences, and structural and functional brain asymmetries.

人类的大脑是横向不对称的。 虽然解剖结构 左边的结构与右边的结构相似 它们之间存在一致的和功能上重要的差异， 特别是在与语言有关的后颞叶区域 处理. 尸体解剖和体外成像研究报告说， 有几个一致的左右差异。 颞平面（PT）， 平均来说，左边的比右边的大。 该表面 与左后颞部的韦尼克区密切相关 耳垂。 然而，由于以前的研究人员使用不同的解剖结构， PT的标准和不同的测量方法，比较 研究之间证明是困难的，并且没有先前的方法似乎是理想的。 以前的工作表明，正常的不对称的PT可能会改变， 在一些精神分裂症患者的大脑中 越来越多的证据 精神分裂症的一些主要症状（幻觉和幻觉） 与左颞叶的变化有关， 提示PT的改变可能与精神分裂症有关 症状 拟议的研究旨在比较对比新旧MRI测量 PT的正常值。 第二个目标是将这些测量应用于 精神分裂症患者和仔细匹配的对照组的PT。 最后，根据以前的研究结果，我们假设， PT的左右不对称可能与特定的 精神分裂症的阳性症状 如果这是真的，它将进一步 了解疾病的生物学基础，提供一个 精神分裂症的一个可识别亚组的可能标志物（ 可能是一种异质性疾病），并表明 这些症状和神经科学中的其他几个活跃领域 研究，特别是语言，性别差异的研究， 大脑结构和功能的不对称