PLANUM TEMPORALE IN SCHIZOPHRENIA

精神分裂症的颞平面

• 批准号: 2250222
• 负责人: PATRICK E BARTA
• 金额: $ 10.92万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2250222
• 关键词: age difference; cerebral dominance; gender difference; human subject; image processing; magnetic resonance imaging; neuroanatomy; phantom model; psychobiology; schizophrenia; socioeconomics; temporal lobe /cortex

The human brain is laterally asymmetric. Although anatomic structures on the left tend to resemble their homologous structure on the right, there are consistent and functionally important differences between them, particularly in the posterior temporal lobe areas involved in language processing. Postmortem and in-vitro imaging studies have reported several consistent left-right differences. The planum temporal (PT) is, on the average, larger on the left than the right. This surface is intimately related to Wernicke's region in the left posterior temporal lobe. Yet, because previous investigators used varying anatomical criteria for PT and different methods for measuring it, comparison between studies proves difficult,and no prior method seems ideal. Previous work suggests that the normal asymmetry of the PT may be altered in some schizophrenic patients' brains. There is increasing evidence that some cardinal symptoms of schizophrenia (hallucinations and though disorder) are associated with changes in the left temporal lobe, suggesting that the PT's changes may be related to schizophrenic symptoms. The proposed study aims to compare the contrast new and old MRI measures of the PT in normals. A second goal is to apply these measurements to the PTs of schizophrenic patients and carefully matched controls. Finally, based on previous findings, we hypothesize that the degrees of left-right asymmetry of the PT is likely to correlate with specified positive symptoms of schizophrenia. If this is true, it would further the understanding of the biological basis of the disorder, provide a possible marker for an identifiable subgroup of schizophrenia (which is probably a heterogeneous disorder), and suggest some connection between these symptoms and several other active areas within neuroscience research, particularly the study of language, gender differences, and structural and functional brain asymmetries.

人脑在侧面是不对称的。 虽然解剖结构 左边倾向于在右侧类似于它们的同源结构， 它们之间存在一致且功能上重要的差异， 特别是在涉及语言的后颞叶区域 加工。 验尸和体外成像研究报告了 几个一致的左右差异。 平面时间（PT）是， 平均而言，左侧比右边大。 这个表面是 与韦尼克（Wernicke）的区域密切相关 叶。 但是，由于以前的研究人员使用了不同的解剖学 PT的标准和测量的不同方法，比较 研究之间证明很困难，没有事先的方法似乎是理想的。 先前的工作表明PT的正常不对称性可能会改变 在一些精神分裂症患者的大脑中。 有越来越多的证据 精神分裂症的一些基本症状（幻觉及其 疾病）与左颞叶的变化有关， 表明PT的变化可能与精神分裂症有关 症状。 拟议的研究旨在比较新的和旧的MRI措施的对比度 正常的PT。 第二个目标是将这些测量结果应用于 精神分裂症患者的PT和仔细匹配的对照。 最后，根据先前的发现，我们假设 PT的左右不对称可能与指定的 精神分裂症的积极症状。 如果这是真的，它将进一步 对疾病的生物学基础的理解，提供了 可识别的精神分裂症亚组的可能标记（即 可能是一种异质性疾病），并提出某种联系 这些症状和神经科学中的其他几个活跃区域 研究，特别是对语言，性别差异和 结构和功能性大脑不对称。