PLANUM TEMPORALE IN SCHIZOPHRENIA

人类的大脑是横向不对称的。虽然解剖结构 左侧倾向于与右侧的同源结构相似， 它们之间有一致的和重要的功能差异， 尤其是在涉及语言的后额叶区域 正在处理。尸检和体外成像研究报告称 几个一致的左右差异。时间平面(PT)是， 平均来说，左边比右边大。这个表面是 与左侧后颞叶WerNicke区关系密切 波瓣。然而，因为之前的研究人员使用了不同的解剖学 PT的标准和不同的测量方法，比较 事实证明，两次研究之间很困难，而且没有一种先前的方法似乎是理想的。 以前的工作表明，PT的正常不对称性可能会改变 在一些精神分裂症患者的大脑中。有越来越多的证据表明 精神分裂症的一些主要症状(幻觉和 紊乱)与左颞叶的变化有关， 提示PT的改变可能与精神分裂症有关 症状。 这项拟议的研究旨在比较新旧MRI措施的对比度 在正常情况下的PT。第二个目标是将这些测量应用于 精神分裂症患者的病例和精心配对的对照组。 最后，根据之前的发现，我们假设 PT的左右不对称很可能与特定的 精神分裂症的阳性症状。如果这是真的，它将进一步 对这种疾病的生物学基础的理解，提供了一种 可识别的精神分裂症亚组的可能标记(这是 可能是一种异质性疾病)，并表明 这些症状和神经科学中的其他几个活跃区域 研究，特别是语言、性别差异的研究，以及 结构和功能上的大脑不对称。

The human brain is laterally asymmetric. Although anatomic structures on the left tend to resemble their homologous structure on the right, there are consistent and functionally important differences between them, particularly in the posterior temporal lobe areas involved in language processing. Postmortem and in-vitro imaging studies have reported several consistent left-right differences. The planum temporal (PT) is, on the average, larger on the left than the right. This surface is intimately related to Wernicke's region in the left posterior temporal lobe. Yet, because previous investigators used varying anatomical criteria for PT and different methods for measuring it, comparison between studies proves difficult,and no prior method seems ideal. Previous work suggests that the normal asymmetry of the PT may be altered in some schizophrenic patients' brains. There is increasing evidence that some cardinal symptoms of schizophrenia (hallucinations and though disorder) are associated with changes in the left temporal lobe, suggesting that the PT's changes may be related to schizophrenic symptoms. The proposed study aims to compare the contrast new and old MRI measures of the PT in normals. A second goal is to apply these measurements to the PTs of schizophrenic patients and carefully matched controls. Finally, based on previous findings, we hypothesize that the degrees of left-right asymmetry of the PT is likely to correlate with specified positive symptoms of schizophrenia. If this is true, it would further the understanding of the biological basis of the disorder, provide a possible marker for an identifiable subgroup of schizophrenia (which is probably a heterogeneous disorder), and suggest some connection between these symptoms and several other active areas within neuroscience research, particularly the study of language, gender differences, and structural and functional brain asymmetries.