CORTICAL SURFACE AREA & THICKNESS IN HEALTH AND DISEASE

我们建议探索唐氏综合征的神经生物学基础， 精神分裂症和双相情感障碍使用新的方法测量皮质 神经解剖学我们将开发和验证测量表面积的方法， 厚度和皮质结构的厚度分布，并使用这些 方法在四个受试者组：健康个体和唐氏症患者 综合症、精神分裂症和双相情感障碍。我们假设表面积 和厚度测量将比常规体积提供更多信息 唐氏综合症患者的大脑皮层会出现 赤字我们相信特定的皮层区域会受到影响， 精神分裂症（异态皮质）和双相情感障碍（内嗅皮质）。 虽然我们在这里关注三种疾病，但我们认为， 对研究其他疾病的研究人员来说也是有用的。我们 计划使我们的软件（用JAVA语言编写，因此可移植到 最流行的计算机，包括C、Mac和Unix系统） 在实验室的网站上。

We propose to explore the neurobiological basis of Down syndrome, schizophrenia, and bipolar disorders using novel methods for measuring cortical neuroanatomy. We will develop and validate methods for measuring surface area, thickness, and thickness distribution of cortical structures, and use these methods in four subject groups: healthy individuals, and patients with Down syndrome, schizophrenia and bipolar disorder. We hypothesize that surface area and thickness measures will be more informative that conventional volume measures, and that patients with Down syndrome will have global cortical deficits. We believe that specific cortical regions will be affected in schizophrenia (heteromodal cortex) and bipolar disorder (entorhinal cortex). Although we focus here on three diseases, we believe that the methods that we will develop would be useful to researchers studying other diseases too. We plan to make our soDware (written in the JAVA language and thus portable to most popular computers including C's, Mac's and Unix-based systems) available on the laboratory's web site.