P300 SYMPTOMS AND THE TEMPORAL LOBE IN SCHIZOPHRENIA

有几种迹象表明精神分裂症可能与 颞叶异常 很多精神分裂症患者 P300听觉诱发反应的音调，和神经发生器， 听觉诱发反应也可以定位在颞叶中， 这表明精神分裂症患者颞叶的异常可能 与临床症状和电生理结果相关。 我们建议检查P300，时间和情绪之间的相互关系。 肺叶结构（通过磁共振成像测量）和阳性 精神分裂症患者和正常人仔细配对组的症状测量 对照 这项研究将与神经系统的基础科学研究有关， P300的基础以及帮助理解 P300异常与精神分裂症症状

There are several suggestions that schizophrenia may be associated with abnormalities in the temporal lobes. Many schizophrenics have abnormal P300 auditory evoked responses to tones, and the neural generator for this auditory evoked response may also be localized in the temporal lobes, suggesting that abnormalities in the temporal lobes of schizophrenics may be related to both clinical symptoms and electrophysiologic findings. We propose to examine the interrelationships between the P300, temporal lobe structures (measured by magnetic resonance imaging) and positive symptom measures in a carefully matched group of schizophrenics and normal controls. The study will be relevant to both basic science research on the neural basis of the P300 as well as help in understanding the connection between P300 abnormalities and schizophrenic symptoms.