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MOTOR AND COMPLEX FUNCTIONS OF BASAL GANGLIA AND CORTEX

MOTOR AND COMPLEX FUNCTIONS OF BASAL GANGLIA AND CORTEX
基底神经节和皮质的运动和复杂功能
批准号:
2263248
负责人:
GARRETT E ALEXANDER
金额:
$25.07万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-07-01 至 1995-06-30

项目摘要

项目成果

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中文摘要
翻译
在本提案中解决的主要问题是:1)电机是否
英文摘要
The principal issues addressed in this proposal are: 1) whether motor processing within the basal ganglia-thalamocortical `motor circuit' is organized, at the neuronal level, in a predominantly serial or parallel fashion; and 2) whether there are systematic transformations, at successive stages of the circuit, in the neural representations of variables that have been implicated in different functional `levels' of motor processing. The proposed studies are designed to determine a) whether the same categories of information (i.e., the same motor variables) are proposed at different stages (cortical, striatal, pallidal, thalamic) of the `motor circuit'; b) whether there are systematic changes in the proportionate representation of a given motor variable by neurons at successive stages of the circuit; and c) whether there are systematic shifts, at successive stages of the circuit, in the regression slopes relating variable-specific changes in neuronal discharge rates to gradations in the represented variables. The Specific Aims for the project are as follows: [1] To determine whether, during the planning and execution of visually guided limb movements, multiple `levels' of motor processing are represented in parallel by neuronal activity within each of the precentral motor fields that contribute to the `motor circuit'. The activity of individual neurons in SMA, MC and APA will be recorded in monkeys performing tasks that require them to make reaching movements to position a cursor in two-dimensional space. The tasks involve both the preparation and execution `modes' of motor processing, and will also dissociate variables relevant to different `levels' of processing viz, target level variables, trajectory/kinematic variables, and dynamic/muscle-related variables. Data from the three areas will then be compared, based on results of both categorical and regression analyses. [2] To determine whether, during the planning and execution of visually guided limb movements, multiple `levels' of motor processing are represented in parallel by neuronal activity at the striatal stage of the `motor circuit'. Task-related single unit activity will be sampled from the arm region of the putamen in monkeys performing the same tasks employed in Specific Aim 1. After being subjected to the same set of analyses, the data will be compared with those obtained in Specific Aim 1. [3] To determine whether, during the planning and execution of visually guided limb movements, multiple `levels' of motor processing are represented in parallel by neuronal activity at the pallidal stage of the `motor circuit'. Task-related single unit activity will be sampled from the arm region of GPi in monkeys performing the same tasks used in Specific Aims 1 and 2. These data will be compared with those obtained in Specific Aim 2, in the same manner as the putamen and cortical data are to be compared. [4] To determine whether, during the planning and execution of visually guided limb movements, multiple `levels' of motor processing are represented in parallel by neuronal activity at the thalamic stage of the `motor circuit'. Task-related single unit activity will be sampled from the are region of VLo in monkeys performing the same tasks used in Specific Aims 1-3. These data will be subjected to the same analyses outlined above, and compared with both a) the SMA data from Specific Aim 1, and b) the GPi data from Specific Aim 3.
期刊论文(7)
专著(0)
科研奖励(0)
会议论文
Selective neuronal discharge in monkey putamen reflects intended direction of planned limb movements.
猴壳核中的选择性神经元放电反映了计划的肢体运动的预期方向。
DOI: 10.1007/bf00247293
发表时间: 1987
期刊: Experimental brain research
影响因子: 2
作者: [Alexander,GE]
通讯作者: Alexander,GE
NEURAL SUBSTRATES FOR CONTROL OF REACHING IN HUMANS
  • 批准号:
    6629334
  • 项目类别:
  • 资助金额:
    $34.2万
  • 财政年份:
    2001
  • 负责人:
    GARRETT E ALEXANDER
  • 依托单位:
NEURAL SUBSTRATES FOR CONTROL OF REACHING IN HUMANS
  • 批准号:
    6499461
  • 项目类别:
  • 资助金额:
    $34.2万
  • 财政年份:
    2001
  • 负责人:
    GARRETT E ALEXANDER
  • 依托单位:
NEURAL SUBSTRATES FOR CONTROL OF REACHING IN HUMANS
  • 批准号:
    6191581
  • 项目类别:
  • 资助金额:
    $36.27万
  • 财政年份:
    2001
  • 负责人:
    GARRETT E ALEXANDER
  • 依托单位:
NEURAL SUBSTRATES FOR CONTROL OF REACHING IN HUMANS
  • 批准号:
    6699083
  • 项目类别:
  • 资助金额:
    $34.2万
  • 财政年份:
    2001
  • 负责人:
    GARRETT E ALEXANDER
  • 依托单位:
海外基金