MOTOR AND COMPLEX FUNCTIONS OF BASAL GANGLIA

核团两个亚区的外在联系模式 灵长类新纹状体提示壳核和尾状核可能 服从不同的功能，壳核主要参与 运动控制，而尾状核参与更复杂的 行为过程。拟议的研究将审查以下程度： 新纹状体在功能上是分化的，并试图 阐明这一结构投射其 基底核输出核团对其他脑区的影响 神经节(特别是苍白球的内段) (GPI))。该项目的具体目标是： 1)使用单细胞记录和微刺激技术检查 壳核参与准备和的假设 执行依赖于指令的马达响应。 2)使用单细胞记录技术检查假设 尾状核的功能分化符合 其异质皮质输入的地形分布，因此可以 在某些特定的初始记忆过程中扮演一个角色 依赖于指令的马达响应，以及b)在编程(和 可能执行)指令相关的眼球跳动 视觉跟踪任务。 3)确定壳核和尾状核是否有独特的 运动中分离的角色和更复杂的行为功能 不完全依赖指令的运动反应，通过比较 保留纤维的神经毒性(鹅膏菌酸)损伤 任务绩效的结构。 4)确定正常的动作以及由 壳核微刺激，依赖于GABA通过 基底神经节的输出核团，通过表征 GPI注射GABA相关药物对两种类型的运动活动都有影响。 这些研究的目的是为了阐明壳核和 尾状核在正常运动和更复杂的行为过程中，以及 还应提供对某些基本机制的洞察 慢性阻塞性肺疾病患者的运动和高级运动控制障碍 基底节疾病，包括帕金森氏症和亨廷顿氏症 疾病。

The patterns of extrinsic connections of the two nuclear subdivisions of the primate neostriatum suggest that the putamen and caudate nucleus may subserve different functions, with the putamen participating principally in motor control while the caudate nucleus is involved in more complex behavioral processes. The studies proposed will examine the degree to which the neostriatum is functionally differentiated, and attempt to clarify some of the mechanisms by which this structure projects its influences to other brain regions via the output nuclei of the basal ganglia (in particular, the internal segment of the globus pallidus (GPi)). The specific aims of the project are: 1) To examine, using single cell recording and microstimulation techniques, the hypothesis that the putamen participates in the preparation for and execution of instruction-dependent motor responses. 2) To examine, using single cell recording techniques, the hypothesis that the caudate nucleus is functionally differentiated in accordance with the topographic distribution of its heterogeneous cortical inputs, and thus may have a role a) in the initial memory processes required for certain instruction-dependent motor responses, and b) in the programing (and possibly execution) of saccadic eye movements in an instruction-dependent visual tracking task. 3) To determine whether the putamen and caudate nucleus have unique and dissociated roles in the motor and more complex behavioral functions which underly instruction-dependent motor responses, by comparing the effects of fiber-sparing neurotoxic (ibotenic acid) lesions of each of these structures on task performance. 4) To determine whether normal movements, as well as those evoked by putamen microstimulation, depend upon GABA-mediated transmission through the output nuclei of the basal ganglia, by characterizing the influence of GPi injections of GABA-related drugs on both types of motor activity. These studies are designed to elucidate the roles of the putamen and caudate nucleus in normal motor and more complex behavioral processes, and should also provide insight into basic mechanisms underlying certain disorders of movement and high-level motor control in patients with diseases of the basal ganglia, including Parkinson's and Huntington's diseases.