SPECIAL PROJECT ON RESEARCH EXCELLENCE--LUNG CANCER

卓越研究特别项目--肺癌

• 批准号: 2098937
• 负责人: JOEL S GREENBERGER
• 金额: $ 21.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2098937
• 关键词: cancer prevention; lung neoplasms; neoplasm /cancer epidemiology

The Pittsburgh Center Institute proposes to organize a SPORE for lung cancer (PCI-LCS) with the overall objective of devising effective strategies for preventing the development of lung cancer and for the treatment of patients after diagnosis of this very common and malignant disease. The proposed research projects are closely interconnected and involve a wide array of basic and clinical expertise, that is being focused on lung cancer. Projects are directed towards elucidating the molecular pathogenesis of this disease and identifying and evaluating biological markers that help to define high risk. Project 2 is focused on a detailed assessment of the whole body and local pulmonary activity of the isoenzymes of the cytochrome P450 system, to understand the genetic heterogeneity in susceptibility to environmental carcinogens and to identify additional biomarkers for risk of lung cancer. Project 3 is an epidemiologic study of heavy smokers at high risk of lung cancer, with a focus on assessment of serum oncoproteins as risk factors. Project 4 is a closely linked case control study of some of the high risk individuals, involving bronchoscopy to obtain HBE for detailed studies of differentiation markers and of P450 enzyme profiles.

匹兹堡中心研究所建议为肺组织一个SPORE 癌症（PCI-LCS）的总体目标是设计有效的 预防肺癌发展的策略， 这种非常常见的恶性肿瘤患者确诊后的治疗 疾病 拟议的研究项目密切相关， 涉及广泛的基础和临床专业知识， 关于肺癌 这些项目旨在阐明 该病的发病机制，并确定和评估生物 有助于定义高风险的标记。 项目2重点是详细的 评估全身和局部肺部同工酶活性 细胞色素P450系统，了解遗传异质性， 对环境致癌物的敏感性，并确定其他 肺癌风险的生物标志物。 项目3是一项流行病学研究， 吸烟者患肺癌的风险高，重点是评估 血清癌蛋白作为危险因素。 项目4是一个密切相关的案件 一些高危人群的对照研究，包括支气管镜检查 以获得HBE用于分化标志物和P450的详细研究 酶谱

项目成果

Oncogene-related serum proteins and cancer risk: a nested case-control study.

癌基因相关血清蛋白和癌症风险：一项巢式病例对照研究。

• DOI: 10.1093/oxfordjournals.aje.a008995
• 发表时间: 1996
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Weissfeld,JL;Larsen,RD;Niman,HL;Kuller,LH
• 通讯作者: Kuller,LH

In vivo expression of p53 and Bcl-2 and their role in programmed cell death in premalignant and malignant lung lesions.

p53 和 Bcl-2 的体内表达及其在癌前和恶性肺部病变中程序性细胞死亡中的作用。

• DOI: 10.1016/s0169-5002(01)00411-1
• 发表时间: 2002
• 期刊: Lung cancer (Amsterdam, Netherlands)
• 作者: Koty,PatrickP;Zhang,Haifan;Franklin,WilburA;Yousem,SamuelA;Landreneau,Rodney;Levitt,MarkL
• 通讯作者: Levitt,MarkL

Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.

膀胱粘膜和肿瘤组织中 CYP2D6 mRNA 多态性表达与体内异喹羟化酶活性的相关性。

• DOI: 10.1093/carcin/15.9.1955
• 发表时间: 1994
• 期刊: Carcinogenesis
• 影响因子: 4.7
• 作者: Romkes-Sparks,M;Mnuskin,A;Chern,HD;Persad,R;Fleming,C;Sibley,GN;Smith,P;Wilkinson,GR;Branch,RA
• 通讯作者: Branch,RA

Differentiation and programmed cell death-related intermediate biomarkers for the development of non-small cell lung cancer: a pilot study.

用于非小细胞肺癌发展的分化和程序性细胞死亡相关中间生物标志物：一项试点研究。

• DOI: 10.1016/s0046-8177(98)90202-7
• 发表时间: 1998
• 期刊: Human pathology
• 影响因子: 3.3
• 作者: Zhang,H;Yousem,SA;Franklin,WA;Elder,E;Landreneau,R;Ferson,P;Keenan,R;Whiteside,T;Levitt,ML
• 通讯作者: Levitt,ML

Activity of anti-erbB-2 recombinant toxin OLX-209 on lung cancer cell lines in the absence of erbB-2 gene amplification.

在没有 erbB-2 基因扩增的情况下，抗 erbB-2 重组毒素 OLX-209 对肺癌细胞系的活性。

• 发表时间: 1996
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research.
• 作者: Kasprzyk,PG;Sullivan,TL;Hunt,JD;Gubish,CT;Scoppa,CA;Oelkuct,M;Bird,R;Fischer,PH;Siegfried,JM;King,CR
• 通讯作者: King,CR