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Molecular Evaluation Of Cobalt Sulfate Lung Neoplasms

Molecular Evaluation Of Cobalt Sulfate Lung Neoplasms
硫酸钴肺肿瘤的分子评价
批准号：
6540981
负责人：
Robert C Sills
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6540981
关键词：
adenoma animal genetic material tag bronchogenic carcinoma chemical carcinogen chemical carcinogenesis chemical related neoplasm /cancer cobalt environmental exposure guanine nucleotide binding protein laboratory mouse lung alveolus lung neoplasms neoplasm /cancer genetics nucleic acid sequence point mutation sulfates tumor suppressor genes

项目摘要

项目成果

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中文摘要
翻译
工作总结：与对照组相比，在暴露于不同浓度的硫酸钴的雄性和雌性小鼠中，硫酸钴诱导了更高的肺泡腺瘤/细支气管腺瘤和癌症的发生率。对来自肺肿瘤的DNA样本进行了K-ras基因点突变测序。在K-ras外显子2中检测到了独特的点突变。该项目的未来工作包括确定独特突变的机制，并表征可能与人类暴露相关的潜在抑癌基因的基因变化。目前，硫酸钴诱发的肺肿瘤与其他肺肿瘤的比较正在进行中。
英文摘要
Summary of Work: Cobalt sulfate induced a higher incidence of alveolar/bronchiolar adenomas and carcinomas in male and female mice exposed to various concentrations of cobalt sulfate compared to controls. DNA samples from lung neoplasms were sequenced for point mutations in the K-ras gene. Unique point mutations were detected in K-ras exon 2. Future work on this project includes determining the mechanism for the unique mutations and characterizing genetic alterations in potential tumor suppressor genes which may be relevant to human exposure. Comparisons between cobalt sulfate induced lung neoplasms and other lung neoplasms are currrently ongoing.
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MRM OF BRAIN LESIONS FOLLOWING CARBONYL SULFIDE EXPOSURE
  • 批准号：
    7358301
  • 项目类别：
  • 资助金额：
    $0.51万
  • 财政年份：
    2006
  • 负责人：
    Robert C Sills
  • 依托单位：
    DUKE UNIVERSITY
MRM OF BRAIN LESIONS FOLLOWING CARBONYL SULFIDE EXPOSURE
  • 批准号：
    7181582
  • 项目类别：
  • 资助金额：
    $0.53万
  • 财政年份：
    2005
  • 负责人：
    Robert C Sills
  • 依托单位：
    DUKE UNIVERSITY
INHALATION TOXICITY OF VOLATILE ORGANIC CHEMICALS--CARBON DISULFIDE
CARBONYL SULFIDE CLEAN AIR ACT STUDIES