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MOLECULAR EVALUATION OF COBALT SULFATE LUNG NEOPLASMS

MOLECULAR EVALUATION OF COBALT SULFATE LUNG NEOPLASMS
硫酸钴肺肿瘤的分子评估
批准号：
6162137
负责人：
H L HONG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6162137
关键词：
adenoma animal genetic material tag bronchogenic carcinoma chemical carcinogen chemical carcinogenesis chemical related neoplasm /cancer cobalt genetic strain laboratory mouse lung alveolus point mutation protooncogene tumor suppressor genes

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英文摘要
Summary of Work: Cobalt sulfate induced a higher incidence of alveolar/bronchiolar adenomas and carcinomas in male and female mice exposed to various concentrations of cobalt sulfate compared to controls. DNA samples from lung neoplasms were sequenced for point mutations in the K-ras gene. Unique point mutations were detected in K-ras exon 2. Future work on this project includes determining the mechanism for the unique mutations and characterizing genetic alterations in potential tumor suppressor genes which may be relevant to human exposure. The findings for the first part of these studies were printed in the NTP Review Board in December 1996.
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