MOLECULAR EVALUATION OF COBALT SULFATE LUNG NEOPLASMS

硫酸钴肺肿瘤的分子评估

• 批准号: 6162137
• 负责人: H L HONG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162137
• 关键词: adenoma; animal genetic material tag; bronchogenic carcinoma; chemical carcinogen; chemical carcinogenesis; chemical related neoplasm /cancer; cobalt; genetic strain; laboratory mouse; lung alveolus; point mutation; protooncogene; tumor suppressor genes

Summary of Work: Cobalt sulfate induced a higher incidence of alveolar/bronchiolar adenomas and carcinomas in male and female mice exposed to various concentrations of cobalt sulfate compared to controls. DNA samples from lung neoplasms were sequenced for point mutations in the K-ras gene. Unique point mutations were detected in K-ras exon 2. Future work on this project includes determining the mechanism for the unique mutations and characterizing genetic alterations in potential tumor suppressor genes which may be relevant to human exposure. The findings for the first part of these studies were printed in the NTP Review Board in December 1996.

工作总结：硫酸钴诱导了较高的 雄性和雌性小鼠的肺泡/细支气管腺瘤和癌 暴露于不同浓度的硫酸钴中。 对来自肺肿瘤的DNA样本进行测序，以确定其在肺肿瘤中的点突变。 K-ras基因。 在K-ras外显子2中检测到独特的点突变。 该项目今后的工作包括确定 独特的突变和表征潜在的遗传改变 肿瘤抑制基因可能与人类接触有关。 的 这些研究的第一部分的结果被印在NTP上 1996年12月审查委员会。