Nanoscale laser cooling in physiological environment

生理环境中的纳米级激光冷却

• 批准号: DE200100074
• 负责人: Dr Fan Wang
• 金额: $ 16.12万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-05-01 至 2022-06-08
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200100074
• 关键词: Nanoscale; laser; cooling; physiological; environment

By developing fluorescence pattern-based 3D motion-detection technology in optical tweezers, this project aims to reveal how to achieve nanoscale laser cooling in physiological media. It plans to discover new mechanisms of cooling associated with surface phonons and energy looping in optically trapped lanthanide-doped nanoparticles. Key expected outcomes are technology and a toolset to create interaction between cooled nanoscale objects and biological samples. These are expected to create a research area of biological laser refrigeration, enabling intracellular organelles cooling, nanoscale membrane disruption and high sensitivity force-sensing for integrin study for use in single-molecule biophysics and multimodality subcellular sensing.

本计画借由发展光镊中以萤光图样为基础的三维运动侦测技术，以揭示如何在生理介质中实现奈米雷射冷却。它计划发现与表面声子和光学捕获的镧系元素掺杂纳米颗粒中的能量循环相关的冷却新机制。关键的预期成果是技术和工具集，以创造冷却纳米级物体和生物样品之间的相互作用。这些有望创建一个生物激光制冷的研究领域，使细胞内细胞器冷却，纳米级膜破裂和高灵敏度的力传感的整合素研究用于单分子生物物理学和多模态亚细胞传感。