INHALATION AND SAMPLING OF LARGE PRTICLES, 10-150 UM

大颗粒的吸入和取样，10-150 UM

• 批准号: 2277815
• 负责人: WILLIAM C HINDS
• 金额: $ 9.37万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1997-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2277815
• 关键词: INHALATION; SAMPLING; LARGE; PRTICLES; 10

The research proposed here will provide comprehensive data on inhalability and personal sampler performance over the particle size range of 10 to 150 micromoles for a wide range of exposure conditions, for liquid and solid particles, and for mouth and nose breathing. Exposure to large particles, 10-150 micromoles, occurs in occupational activities such as mining, woodworking, painting, pesticide application, grinding, and mineral processing. Generally, large particles such as heavy metals, pesticides, radioactive materials, and corrosives are harmful if inhaled, regardless of where they deposit in the respiratory system. Occupational health professionals need to know what fraction of large particles will be inhaled under different conditions, and how well different types of samplers collect these particles. Few data are available on the inhalation of large particles and the performance of samplers for these particles. For example, for particles greater than 30 micromoles, there are no data on inhalability for liquid particles, for nasal inhalation, and for sampling performance of 37 mm filter cassettes. Data for solid particles greater than 60 micromoles come from only one laboratory. Experimental measurements of these quantities under simulated industrial conditions are needed to support standards based on recent ACGIH and CEN sampling criteria for inhalable particulate matter (IPM). The proposed research will be conducted using UCLA's fully operational low-velocity wind tunnel to simulate, under controlled conditions, air motion typical of indoor work environments. Specific test conditions for solid and liquid particles are: eight particle sizes (10-150 micromoles), three air velocities (0.4-1.8 m/s), three breathing profiles (work rate of 0-102 W), two orientations (0 degrees and orientation average), and three replications for each condition. Personal sampler evaluation will include current "total," IPM, and prototype IPM samplers over the same range of conditions for solid and liquid particles.

这里提出的研究将提供关于可吸入性的全面数据 和个人采样器在10至150粒度范围内的性能 微摩尔，适用于液体和固体的各种暴露条件 颗粒，以及用于嘴和鼻子呼吸。 暴露于10-150微摩尔的大颗粒物，发生在职业性 采矿、木工、油漆、农药施用等活动， 研磨和矿物加工。一般来说，大颗粒，如重 金属、杀虫剂、放射性物质和腐蚀性物质是有害的， 吸入，无论它们在呼吸系统的何处存款。 职业健康专业人员需要知道大部分 在不同的条件下，颗粒会被吸入， 不同类型的采样器收集这些颗粒。很少有数据 可对吸入性大颗粒物的性能进行检测， 这些粒子的取样器例如，对于大于30 微摩尔，没有关于液体颗粒可吸入性的数据， 鼻吸入和37 mm过滤盒的采样性能。 大于60微摩尔的固体颗粒的数据仅来自一个 实验室模拟条件下这些量的实验测量 需要工业条件来支持基于最近 ACGIH和CEN可吸入颗粒物（IPM）采样标准。 拟议的研究将使用加州大学洛杉矶分校的全面运作， 低速风洞，在受控条件下模拟空气 室内工作环境中的典型运动。具体试验条件 固体和液体颗粒是：八种颗粒尺寸（10-150微摩尔）， 三种空气速度（0.4-1.8 m/s），三种呼吸曲线（工作速率为 0-102 W）、两个方向（0度和方向平均值）和三个方向 每种情况下的复制。个人采样器评价将包括 目前的“总”，IPM，和原型IPM采样器在同一范围内的 固体和液体颗粒的条件。