CHRONIC STRESS EFFECT ON CALMING POSTMATURE INFANTS

慢性压力对早产儿镇静的影响

• 批准号: 2249642
• 负责人: BARBARA A SMITH
• 金额: $ 7.46万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2249642
• 关键词: adrenocorticotropic hormone; blood chemistry; chronic disease /disorder; cryings; endorphins; gestational age; human subject; infant human (0-1 year); oral behavior; prenatal stress; psychophysiology; radioimmunoassay; stimulus /response; sucrose

General and Specific Aims: The general aim of this study is to explore the effects of prenatal stress on calming in infants born with Clifford's postmaturity syndrome. Specifically, the proposed experiments are designed to address the following questions: l) Do postmature infants have elevated postnatal B-endorphin and ACTH levels compared to term infants, and, if so, will the stage of Clifford's syndrome at which s/he has been diagnosed, correspond with the degree of elevation of the physiological measures? 2) Will B-endorphin a ACTH levels at birth predict (negatively) the ability of a sweet stimulus to calm irritable postmature infants? 3) Do postmature and healthy term infants differ in their calming responses to intraoral tactile stimulation via a pacifier? The proposed study is comprised of two experiments. In Experiment l, infants will be assigned to either one of three conditions: infants receiving sucrose will be given a 0.1 ml aliquot of either a 14% or 24% sucrose solution (weight/volume) delivered for 10 sec, once/min, over a 5- minute period. The same protocol will be used to administer sterile water to infants assigned to the water condition. Infants in Experiment 2 will receive a blank pacifier for 15 minutes. The dependent variables will be time spent crying during the test phases (stimulation and poststimulation), and B-endorphin and ACTH levels at birth. Long-Term Objectives: It is expected that these findings will increase our understanding of processes underlying oral events and their relationship to affective states in human neonates. In addition to expanding our knowledge of the mechanisms mediating calming in healthy human infants, these findings will also provide information regarding infants born with Clifford's postmaturity syndrome. Furthermore, such findings would predict diminished reactivity to sucrose in opiate-tolerant and other prenatally stressed infants and would serve as the basis for recommendation of interventions.

总体和具体目标：本研究的总体目标是探索 产前应激对先天性克利福德综合征患儿镇静能力的影响 过熟综合症 具体而言，拟议的实验是 旨在解决以下问题： l）早产儿是否有出生后升高的B-内啡肽和ACTH 与足月婴儿相比的水平，如果是这样，克利福德的阶段会 他/她被诊断出的综合征，与 生理指标的提升？ 2)出生时的B-内啡肽和ACTH水平是否会（负面）预测 甜的刺激物能使易怒的过熟婴儿平静下来吗？ 3)过熟儿和健康足月儿在镇静方面是否有差异 通过奶嘴对口内触觉刺激的反应？ 该研究由两个实验组成。 在实验1中， 婴儿将被分配到以下三种情况之一： 接受蔗糖的患者将被给予0.1 ml等份的14%或24%的 蔗糖溶液（重量/体积），递送10秒，一次/分钟，超过5- 分钟周期。 将使用相同的方案来给予无菌水 分配到水环境中的婴儿。 实验2中的婴儿将 接受空白奶嘴15分钟。 因变量为 在测试阶段（刺激和 刺激后），以及出生时的B-内啡肽和ACTH水平。 长期目标：预计这些发现将增加我们的 理解口语事件背后的过程及其关系 人类新生儿的情感状态。 除了扩大我们的 了解健康人类婴儿中调节平静的机制， 这些发现还将提供有关出生时患有 克利福德过熟综合征。 此外，这些调查结果将 预测阿片类药物耐受者和其他 产前压力的婴儿，并将作为基础， 干预建议。