NEUROPSYCHOPHARMACOLOGY OF ALTERED CONSCIOUSNESS
意识改变的神经心理药理学
基本信息
- 批准号:2115866
- 负责人:
- 金额:$ 9.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1977
- 资助国家:美国
- 起止时间:1977-07-01 至 1997-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This is a request for continuation of a Research Scientist Award. My
broadest objectives are to understand why people take psychoactive drugs,
what are usual and expected effects, what might account for unexpected
consequences and how might adverse consequences best be managed. For
example, how might tolerance and dependence determine individual
differences in drug use and drug effects? Individual projects study the
pharmacokinetics and pharmacodynamics of cocaine and methamphetamine
administered by various routes, and interactions with other drugs; for
example, ethanol, caffeine and nicotine. Characteristics of tolerance and
dependence associated with repeated dose subchronic cocaine administration
and the utility of that experimental paradigm to evaluate new treatment
medications will be studied. In other drug kinetic studies, the appearance
of drug and drug metabolites in hair, saliva and sweat is being
investigated to better understand and model drug disposition and to assess
the utility of those media to characterize individual patterns of drug use
and drug kinetics. Characterization of the pharmacokinetics and dynamics
of buprenorphine and its metabolites and factors altering such effects is
studied as part of the evaluation of pharmacologic treatments for opiate,
cocaine and related dependence. Whenever possible, equal attention is
given to psychological and behavioral measures, assessment of mood,
neurophysiological and neurochemical indices. In the clinical studies,
emphasis is on understanding relationships between behavioral,
physiological and pharmacologic variables. Biochemical, physiologic,
neuroendocrinologic, behavioral and psychometric technique are used to
assess consequences of acute and subchronic drug administration.
Recognizing that people rarely limit drug taking to a single drug or class
of drugs, development and application of research strategies appropriate to
the study of multiple classes of drugs rather than specialization with a
particular methodology or drug class is a guiding philosophy. Where
possible, mechanisms and explanations for individual differences in drug
effects are studied. Relationships between naturally occurring and drug-
induced disorders (for example, depression, anxiety states, and
schizophrenia or other psychosis) remain a topic of interest. The studies
are multidisciplinary and involve only human subjects. They should further
understanding of human psychoactive drug use and its health consequences
and management.
这是一项延续研究科学家奖的请求。我的
最广泛的目标是了解人们为什么服用精神活性药物,
常见的和预期的影响是什么?意外的原因是什么
以及如何才能最好地管理不良后果。为
例如,宽容和依赖如何决定个人
在药物使用和药物效果方面的差异?个别计划研究
可卡因和甲基苯丙胺的药代动力学和药效学
通过各种途径给药,以及与其他药物的相互作用;
例如,乙醇、咖啡因和尼古丁。容忍度的特点和
亚慢性可卡因反复给药的依赖关系
以及这一实验范式在评估新疗法方面的效用
将对药物进行研究。在其他药物动力学研究中,出现了
头发、唾液和汗液中的药物和药物代谢物
进行调查以更好地理解和模拟药物处置并评估
利用这些媒体来描述药物使用的个别模式
和药物动力学。药代动力学和动力学的表征
丁丙诺啡及其代谢物和改变这种作用的因素
作为阿片类药物药物治疗评估的一部分进行研究,
可卡因和相关依赖。只要有可能,同等的关注是
习惯于心理和行为测量,情绪评估,
神经生理和神经化学指标。在临床研究中,
重点是了解行为和行为之间的关系,
生理和药理学变量。生化,生理学,
神经内分泌学、行为学和心理测量学技术用于
评估急性和亚慢性给药的后果。
认识到人们很少将吸毒限制在一种药物或一类药物上
药物,开发和应用适当的研究战略
对多类药物的研究,而不是用一种
特定的方法论或药物类是指导哲学。哪里
药物个体差异的可能、机制和解释
对影响进行了研究。自然发生与药物之间的关系-
诱导性障碍(例如,抑郁、焦虑状态和
精神分裂症或其他精神病)仍然是一个令人感兴趣的话题。这些研究
是多学科的,只涉及人类受试者。他们应该进一步
了解人类精神活性药物的使用及其对健康的影响
和管理。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Reese T. Jones其他文献
Effect of disulfiram on cognition, subjective response, and cortical-event-related potentials in nonalcoholic subjects.
双硫仑对非酒精受试者认知、主观反应和皮质事件相关电位的影响。
- DOI:
- 发表时间:
1979 - 期刊:
- 影响因子:0
- 作者:
S. Peeke;A. Ruth Prael;R. Herning;W. Rogers;N. Benowitz;Reese T. Jones - 通讯作者:
Reese T. Jones
Marijuana, alcohol, and combined drug effects on the time course of glare recovery
- DOI:
10.1007/bf00571413 - 发表时间:
1978-01-01 - 期刊:
- 影响因子:3.300
- 作者:
Anthony J. Adams;Brian Brown;Gunilla Haegerstrom-Portnoy;Merton C. Flom;Reese T. Jones - 通讯作者:
Reese T. Jones
Naloxone-induced mood and physiologic changes in normal volunteers
纳洛酮引起的正常志愿者情绪和生理变化
- DOI:
10.1007/978-1-349-04015-5_44 - 发表时间:
1979 - 期刊:
- 影响因子:2.4
- 作者:
Reese T. Jones;R. Herning - 通讯作者:
R. Herning
Combined effects of alcohol and sleep deprivation in normal young adults
酒精和睡眠不足对正常年轻人的综合影响
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:3.4
- 作者:
S. Peeke;E. Callaway;Reese T. Jones;G. Stone;Joseph S. Doyle - 通讯作者:
Joseph S. Doyle
Dissociation of autonomic and cognitive effects of THC in man
THC 对人类自主神经和认知作用的分离
- DOI:
10.1007/bf00426733 - 发表时间:
1979 - 期刊:
- 影响因子:3.4
- 作者:
J. Bachman;N. Benowitz;R. Herning;Reese T. Jones - 通讯作者:
Reese T. Jones
Reese T. Jones的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Reese T. Jones', 18)}}的其他基金
FOOD EFFECT BIOAVAILABILITY STUDY OF RPR102681 IN HEALTHY NORMAL VOLUNTEERS
RPR102681 在健康正常志愿者中的食物效应生物利用度研究
- 批准号:
7203042 - 财政年份:2004
- 资助金额:
$ 9.76万 - 项目类别:
PK STUDY OF 75, 15, AND 30 MG OF SUBLINGUAL LOBELINE
75、15 和 30 MG 舌下叶边碱的药代动力学研究
- 批准号:
7203034 - 财政年份:2004
- 资助金额:
$ 9.76万 - 项目类别:
Food effect bioavailability study of RPR102681 in healthy normal volunteers
RPR102681在健康正常志愿者中的食物效应生物利用度研究
- 批准号:
7044954 - 财政年份:2003
- 资助金额:
$ 9.76万 - 项目类别:
Pharmacokinetics of drugs of abuse in skin and hair
滥用药物在皮肤和头发中的药代动力学
- 批准号:
6566794 - 财政年份:2001
- 资助金额:
$ 9.76万 - 项目类别:
Pharmacokinetics of drugs of abuse in skin and hair
滥用药物在皮肤和头发中的药代动力学
- 批准号:
6469323 - 财政年份:2000
- 资助金额:
$ 9.76万 - 项目类别:
CLINICAL STUDIES OF COCAINE TOLERANCE, SENSITIZATION AND WITHDRAWAL
可卡因耐受性、致敏性和戒断的临床研究
- 批准号:
6318333 - 财政年份:2000
- 资助金额:
$ 9.76万 - 项目类别:
相似海外基金
Cannabinoids, Inflammation/Infection and Microglia: Relation to Brain and Behaviour
大麻素、炎症/感染和小胶质细胞:与大脑和行为的关系
- 批准号:
502602 - 财政年份:2024
- 资助金额:
$ 9.76万 - 项目类别:
Peripherally-restricted non-addictive cannabinoids for cancer pain treatment
用于癌症疼痛治疗的外周限制性非成瘾大麻素
- 批准号:
10726405 - 财政年份:2023
- 资助金额:
$ 9.76万 - 项目类别:
Indiana University Bloomington (IUB) Center for Cannabis, Cannabinoids, and Addiction (C3A)
印第安纳大学伯明顿分校 (IUB) 大麻、大麻素和成瘾中心 (C3A)
- 批准号:
10713089 - 财政年份:2023
- 资助金额:
$ 9.76万 - 项目类别:
Defining the impact of cannabinoids on the HIV reservoir in humanized mice
确定大麻素对人源化小鼠 HIV 储存库的影响
- 批准号:
10814024 - 财政年份:2023
- 资助金额:
$ 9.76万 - 项目类别:
Computation-assisted discovery of bioactive minor cannabinoids from hemp
计算辅助从大麻中发现生物活性次要大麻素
- 批准号:
10791213 - 财政年份:2023
- 资助金额:
$ 9.76万 - 项目类别:
A triple-blind, placebo-controlled, randomized clinical trial of CANnabinoids for Drug Resistant Epilepsy (CAN-DRE) in adults and children
大麻素治疗成人和儿童耐药性癫痫 (CAN-DRE) 的三盲、安慰剂对照、随机临床试验
- 批准号:
479757 - 财政年份:2023
- 资助金额:
$ 9.76万 - 项目类别:
Operating Grants
Elusidation for Toxicity Mechanism of Synthetic Cannabinoids by Multi-omics Approach: Focusing on Cardiovascular System
多组学方法阐明合成大麻素的毒性机制:聚焦心血管系统
- 批准号:
23K09762 - 财政年份:2023
- 资助金额:
$ 9.76万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
On-demand continuous flow manufacturing of cannabidiol (CBD) and other cannabinoids
大麻二酚 (CBD) 和其他大麻素的按需连续流制造
- 批准号:
570513-2021 - 财政年份:2022
- 资助金额:
$ 9.76万 - 项目类别:
Alliance Grants
Inhibition of visceral sensation by cannabinoids in the gastrointestinal tract
大麻素在胃肠道中抑制内脏感觉
- 批准号:
RGPIN-2021-03491 - 财政年份:2022
- 资助金额:
$ 9.76万 - 项目类别:
Discovery Grants Program - Individual
The Impact of Cannabinoids on Heart Development in Zebrafish
大麻素对斑马鱼心脏发育的影响
- 批准号:
486076 - 财政年份:2022
- 资助金额:
$ 9.76万 - 项目类别:
Studentship Programs