DNA repair: a critical quality control mechanism in the female germ line

DNA 修复：雌性生殖系的关键质量控制机制

• 批准号: FT190100265
• 负责人: Prof Karla Hutt
• 金额: $ 56.8万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT190100265
• 关键词: DNA; repair; critical; quality; control

This project aims to investigate the fundamental biological mechanisms required for the production of high quality gametes, which underpin female fertility and the propagation of all sexually reproducing species. By taking advantage of unique mouse and avian models, this project expects to define the role of the DNA repair protein TOP3A in the successful completion of meiosis and it's requirement for the survival and genetic integrity of gametes throughout their lifespan. In doing so, the intended outcome of this project is to dramatically improve our understanding of quality control in the female germ line. This should provide significant benefits to Australia by positioning it as a world leader in the field of Reproductive Science.

该项目旨在研究产生高质量配子所需的基本生物学机制，这是雌性生育和所有有性繁殖物种繁殖的基础。通过利用独特的小鼠和鸟类模型，该项目希望确定DNA修复蛋白TOP3A在成功完成减数分裂中的作用，以及它对配子在整个生命周期中的生存和遗传完整性的要求。通过这样做，这个项目的预期结果是极大地提高我们对雌性生殖细胞系质量控制的理解。这将为澳大利亚定位为生殖科学领域的世界领先者，从而为其带来巨大的好处。