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STRUCTURE OF TOXIC POLYPEPTIDES FROM SEA ANEMONES

STRUCTURE OF TOXIC POLYPEPTIDES FROM SEA ANEMONES
海葵有毒多肽的结构
批准号:
2292345
负责人:
LAWRENCE Jules BERLINER
金额:
$1.8万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
未结题
起止时间:
1994-12-22 至

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中文摘要
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英文摘要
The goals of this research are to understand the molecular basis of the interactions of several neurotoxic polypeptides from sea anemones by first elucidating their-dimensional structure in solution by state-of- the-art NMR and related techniques (ESR spin labeling, CIDNP) The combined results of these approaches allow us to define both the average and dynamic structures of, e.g., tenebrosins-A, -B, and -C from the Australian sea anemone. The experimental approaches will involve collaborative molecular biological approaches as well, allowing specific isotopic labeling for higher order (3-D, 4-D) NMR studies. Following a 6-month visit, two annual 3-month visits are planned with ESR an CIDNP studies at Ohio State in the interim.
期刊论文(1)
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会议论文
Preparation and characterization of a biologically active spin-labeled sea anemone toxin.
生物活性自旋标记海葵毒素的制备和表征。
DOI: 10.1007/bf01886849
发表时间: 1996
期刊: Journal of protein chemistry
影响因子: --
作者: [Monks,SA, Norton,RS, Curtain,CC, Berliner,LJ]
通讯作者: Berliner,LJ
Aviv Model 215 Circular Dichroism Sepctrometer
DETERMINANTS OF CALCIUM BINDING IN NON EF HAND PROTEINS
DETERMINANTS OF CALCIUM BINDING IN NON EF HAND PROTEINS
  • 批准号:
    6180833
  • 项目类别:
  • 资助金额:
    $20.58万
  • 财政年份:
    1998
  • 负责人:
    LAWRENCE Jules BERLINER
  • 依托单位:
DETERMINANTS OF CALCIUM BINDING IN NON EF HAND PROTEINS
  • 批准号:
    6019403
  • 项目类别:
  • 资助金额:
    $19.16万
  • 财政年份:
    1998
  • 负责人:
    LAWRENCE Jules BERLINER
  • 依托单位:
国内基金
海外基金
Glymphatic系统功能损害影响toxic milk小鼠脑铜清除的机制研究
  • 批准号:
    81701122
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.0万元
  • 批准年份:
    2017
  • 负责人:
    陈定邦
  • 依托单位: