STRUCTURE OF TOXIC POLYPEPTIDES FROM SEA ANEMONES

海葵有毒多肽的结构

• 批准号: 2292345
• 负责人: LAWRENCE Jules BERLINER
• 金额: $ 1.8万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-22 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2292345
• 关键词: STRUCTURE; TOXIC; POLYPEPTIDES; SEA; ANEMONES

The goals of this research are to understand the molecular basis of the interactions of several neurotoxic polypeptides from sea anemones by first elucidating their-dimensional structure in solution by state-of- the-art NMR and related techniques (ESR spin labeling, CIDNP) The combined results of these approaches allow us to define both the average and dynamic structures of, e.g., tenebrosins-A, -B, and -C from the Australian sea anemone. The experimental approaches will involve collaborative molecular biological approaches as well, allowing specific isotopic labeling for higher order (3-D, 4-D) NMR studies. Following a 6-month visit, two annual 3-month visits are planned with ESR an CIDNP studies at Ohio State in the interim.

这项研究的目的是了解的分子基础

项目成果

Preparation and characterization of a biologically active spin-labeled sea anemone toxin.

生物活性自旋标记海葵毒素的制备和表征。

• DOI: 10.1007/bf01886849
• 发表时间: 1996
• 期刊: Journal of protein chemistry
• 作者: Monks,SA;Norton,RS;Curtain,CC;Berliner,LJ
• 通讯作者: Berliner,LJ