SOLUBLE RECEPTORS, ANTIBODIES & IMMUNOGLOBULINS-ELISA

可溶性受体、抗体

• 批准号: 3701942
• 负责人: NORMAN BEAUDRY
• 金额: $ 28.2万
• 依托单位: COVANCE LABORATORIES, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-30 至 1997-06-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3701942
• 关键词: Macaca fascicularis; animal tissue; antibody titering; bacterial antigens; communicable disease diagnosis; cytokine receptors; enzyme linked immunosorbent assay; hemagglutination test; human tissue; humoral immunity; immunodeficiency; immunoglobulins; injection /infusion; interleukin 2; lymphocyte; monoclonal antibody; neoplasm /cancer immunodiagnosis; neoplasm /cancer immunology; polysaccharides; serum globulins; tissue /cell culture; transfection

The main objectives of this contract are for the contractor to perform enzyme linked immunosorbent assays (ELISA's) for soluble interleukin-2 receptors, for the contractor to assay human and cynomologus monkey antibodies directed toward both infused murine and humanized monoclonal antibodies, for the contractor to determine serum concentration of infused murine and humanized antibodies, and for the contractor to perform passive hemagglutination assays and ELISA's for serum antibodies to protein and polysaccharide antigens. These assays are integral parts of major ongoing clinical trials of the intramural research program, and are mandated by the Bureau of Biologics for ongoing intramural clinical trials. The assays represent repetitive procedures that are part of this integrated continuing program of the Metabolism Branch, NCI. Data obtained under this contract must be consistent with previous data, and delivered in a timely manner to the Project Officer and Metabolism Branch Staff, since results will be used for clinical care decisions made in real time.

本合同的主要目的是让承包商履行 可溶性白细胞介素-2的酶联免疫吸附测定（ELISA） 受体，供承包商检测人类和食蟹猴 针对输注的鼠和人源化单克隆抗体 抗体，供承包商测定血清中 输注鼠和人源化抗体，并为承包商， 对血清抗体进行被动血凝试验和ELISA 蛋白质和多糖抗原。 这些检测是 校内研究项目正在进行的主要临床试验，以及 由生物制品局授权进行内部临床试验 审判 这些测定代表了重复的程序，这些程序是本发明的一部分。 NCI代谢分支的综合持续计划。 数据 根据本合同获得的数据必须与以前的数据一致， 及时交付给项目官员和代谢分支 工作人员，因为结果将用于临床护理决策 真实的时间。