STUDIES ON ISOPRENE, INDIUM PHOSPHIDE, GALLIUM ARSENIDE

该项目的目标是确定潜在的毒性和 异戊二烯、磷化铟、砷化镓和氯化镓的致癌性 Fischer 344大鼠和B6C3Fl吸入戊二醛 老鼠。每种化学品的基本奖项包括开发 分析化学以及产生和监测方法。一旦这些 方法已经充分发展，毒性/致癌性研究 是要进行的。 异戊二烯：将进行为期104周的研究，涉及50人 动物/性别/物种，3个暴露浓度加对照；活体内 大鼠和小鼠的遗传毒性研究在前30天 曝光。 磷化铟：将进行为期13周的研究，涉及10个 动物/性别/物种，5个暴露浓度加对照； 大鼠血液学和临床化学，小鼠血液学；活体 大鼠和小鼠的遗传毒性研究在前30天 暴露.全血、血清和血清中铟浓度的测定 睾丸和肺部。 将进行为期104周的研究，涉及50只动物/性别/物种， 在3种暴露浓度和对照条件下.铟的测定 全血、血清、睾丸和肺中的浓度。 砷化镓：将进行为期104周的研究，涉及50人 动物/性别/物种，3个暴露浓度加对照；活体内 大鼠和小鼠的遗传毒性研究在前30天 暴露.整体镓和砷浓度的测定 血液、血清、睾丸和肺。 戊二醛的任选研究：将进行为期104周的研究， 涉及50只动物/性别/物种，在3个暴露浓度加上 控制。

The objective of this project is to determine the potential toxicity and carcinogenicity of isoprene, indium phosphide, gallium arsenide, and optionally glutaraldehyde, by inhalation to Fischer 344 rats and B6C3Fl mice. The basic award for each chemical includes the development of analytical chemistry and generation and monitoring methods. Once these methods have been adequately developed, toxicity/carcinogenicity studies are to be conducted. Isoprene: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure. Indium phosphide: 13-week study is to be conducted, involving ten animals/sex/species, at 5 exposure concentrations plus controls; hematology and clinical chemistry in rats, hematology in mice; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure; determination of indium concentrations in whole blood, serum, testes and lung. 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; determination of indium concentrations in whole blood, serum, testes and lung. Gallium arsenide: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure; determination of gallium and arsenic concentrations in whole blood, serum, testes and lung. Optional study of Glutaraldehyde: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls.