ISOPRENE, INDIUM PHOSPHIDE, GALLIUM ARSENIDE

异戊二烯、磷化铟、砷化镓

• 批准号: 6146874
• 负责人: BILLY J CHOU
• 金额: --
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1988-07-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6146874
• 关键词: arsenic; clinical chemistry; gallium; glutaraldehyde; hematology; indium; laboratory mouse; laboratory rat; organic chemicals; physical chemical interaction

The objective of this project is to determine the potential toxicity and carcinogenicity of isoprene, indium phosphide, gallium arsenide, and optionally glutaraldehyde, by inhalation to Fischer 344 rats and B6C3Fl mice. The basic award for each chemical includes the development of analytical chemistry and generation and monitoring methods. Once these methods have been adequately developed, toxicity/carcinogenicity studies are to be conducted. Isoprene: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure. Indium phosphide: 13-week study is to be conducted, involving ten animals/sex/species, at 5 exposure concentrations plus controls; hematology and clinical chemistry in rats, hematology in mice; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure; determination of indium concentrations in whole blood, serum, testes and lung. 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; determination of indium concentrations in whole blood, serum, testes and lung. Gallium arsenide: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls; in vivo genotoxicity studies in rats and mice during the first 30 days of exposure; determination of gallium and arsenic concentrations in whole blood, serum, testes and lung. Optional study of Glutaraldehyde: 104-week study is to be conducted, involving fifty animals/sex/species, at 3 exposure concentrations plus controls.

本项目的目的是确定潜在的毒性， 异戊二烯、磷化铟、砷化镓和 任选戊二醛，通过吸入Fischer 344大鼠和B6 C3 F1 小鼠 每种化学品的基本奖项包括开发 分析化学、生成和监测方法。 一旦这些 方法已充分开发，毒性/致癌性研究 将被执行。 异戊二烯：将进行104周研究，涉及50名 动物/性别/种属，3种暴露浓度+对照;体内 前30天内大鼠和小鼠的遗传毒性研究 exposure. 磷化铟：将进行13周研究，涉及10名 动物/性别/种属，5个暴露浓度加对照组; 大鼠血液学和临床化学，小鼠血液学;体内 前30天内大鼠和小鼠的遗传毒性研究 暴露;全血，血清， 睾丸和肺 104-将进行为期一周的研究，涉及50只动物/性别/种属， 在3种接触浓度加对照浓度下.铟的测定 全血、血清、睾丸和肺中的浓度。 砷化镓：将进行104周研究，涉及50名 动物/性别/种属，3种暴露浓度+对照;体内 前30天内大鼠和小鼠的遗传毒性研究 暴露.镓和砷总浓度的测定 血液血清睾丸和肺 戊二醛的可选研究：将进行104周研究， 涉及50只动物/性别/种属，3个暴露浓度加 对照